Radial glial cells: Key organisers in CNS development.
File Type:Microsoft Word
Item Type:Journal Article
Citation:Denis Barry, Janelle Pakan and Kieran McDermott, Radial glial cells: Key organisers in CNS development., The International Journal of Cell Biology and Biochemistry, 46, 76-79, 2014, 76 - 79
RADIAL GLIAL CELLS. key organisers in CNS development.docx (Published (author's copy) - Peer Reviewed) 1.963Mb
Radial glia are elongated bipolar cells present in the CNS during development. Our understanding of the unique roles these cells play has significantly expanded in the last decade. Historically, radial glial cells were primarily thought to provide an architectural framework for neuronal migration. Recent research reveals that radial glia play a more dynamic and integrated role in the development of the brain and spinal cord. They represent a major progenitor pool during early development and can give rise to a small population of multipotent cells in neurogenic niches of the adult CNS. Radial glial cells are a heterogeneous population, with divergent and often poorly understood roles across different brain and spinal cord regions during development; this heterogeneity extends to specialised adult subtypes, such as tanycytes, Muller glial cells and Bergman glial cells which possess morphological similarities to radial glial but play distinct functional roles in the CNS.
Author: Barry, Denis
Type of material:Journal Article
Series/Report no:The International Journal of Cell Biology and Biochemistry
Availability:Full text available
DOI:adial glial cells: Key organisers in CNS development