Browsing Psychiatry by Author "Bokde, Arun"

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  • Basal forebrain volume, but not hippocampal volume, is a predictor of global cognitive decline in patients with alzheimer's disease treated with cholinesterase inhibitors 

    Bokde, Arun; Teipel, Stefan J.; Cavedo, Enrica; Hampel, Harald; Gothe, Michel J. (2018)
    Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes ...

  • Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD 

    Bokde, Arun; Vergallo, Andrea; Houot, Marion; Cavedo, Enrica; Lemercier, Pablo; Vanmechelen, Eugeen; De Vos, Ann; Habert, Marie-Odile; Potier, Marie-Claude; Dubois, Bruno; Lista, Simone; Hampel, Harald; the INSIGHT-preAD study group; the Alzheimer Precision Medicine Intitiative (APMI) (2019)
    Introduction: Successful development of effective β-site amyloid precursor protein cleaving enzyme 1 (BACE1)–targeted therapies for early stages of Alzheimer's disease requires biomarker-guided intervention strategies ...

  • Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease 

    Bokde, Arun; Chiesa, Patrizia A.; Cavedo, Enrica; Vergallo, Andrea; Lista, Simone; Potier, Marie-Claude; Habert, Marie-Odile; Dubois, Bruno; Thiebaut de Schotten, Michel; Hampel, Harald; the INSIGHT-preAD study group; the Alzheimer Precision Medicine Intitiative (APMI) (2019)
    Introduction: The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer's disease are poorly understood. Methods: In a large-scale monocentric ...

  • Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability? 

    Bokde, Arun; Whelan, Robert; Kaminski, Jakob A.; Schlagenhauf, Florian; Rapp, Michael; Awasthi, Swapnil; Ruggeri, Barbara; Deserno, Lorenz; Banaschewski, Tobias; Bromberg, Uli; Büchel, Christian; Burke Quinlan, Erin; Desrivieres, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Ittermann, Bernd; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tomáš; Poustka, Luise; Smolka, Michael N.; Fröhner, Juliane H.; Walter, Henrik; Ripke, Stephan; Schumann, Gunter; Heinz, Andreas; the IMAGEN consortium (2018)
    Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to ...

  • Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group 

    Bokde, Arun; Whelan, Robert (2019)
    DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues ...

  • Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis 

    Bokde, Arun; Whelan, Robert; Velthorst, Eva; Froudist-Walsh, Sean; Ruderfer, Douglas; Ivanov, Ilyan; Buxbaum, Joseph; iPSYCH-Broad ASD Group; the IMAGEN consortium; Banaschewski, Tobias; Brobmerg, Uli; Büchel, Christian; Burke Quinlan, Erin; Desrivieres, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Paillère Martinot, Marie-Laure; Artiges, Eric; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Walter, Henrik; Schumann, Gunter; Reichenberg, Abraham (2018)
    While psychotic experiences (PEs) are assumed to represent psychosis liability, general population studies have not been able to establish significant associations between polygenic risk scores (PRS) and PEs. Previous work ...

  • Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence. 

    Bokde, Arun; Whelan, Robert; Orr, Catherine; Spechler, Philip; Cao, Zhipeng; Albaugh, Matthew; Chaarani, Bader; Mackey, Scott; D'Souza, Deepak; Allgaier, Nicholas; Banaschewski, Tobias; Bromberg, Uli; Büchel, Christian; Burke Quinlan, Erin; Conrod, Patricia; Desrivieres, Sylvane; Flor, Herta; Frouin, Vincent; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Paus, Tomáš; Poustka, Luise; Millenet, Sabina; Fröhner, Juliane H.; Radhakrishnan, Rajiv; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Potter, Alexandra; Garavan, Hugh (2019)
    Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially ...

  • No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer???s disease 

    Bokde, Arun; Kennelly, Sean (2019)
    Introduction: The earliest changes in the brain due to Alzheimer’s disease are associated with the neural networks related to memory function. We investigated changes in functional and structural connectivity among ...