Browsing Psychiatry by Title
Now showing items 131-150 of 159
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A Randomized, Controlled Trial With 6-Month Follow-Up of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy for Severe Depression
(American Psychiatric Association, 2007)OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) has been reported to be as effective as electroconvulsive therapy (ECT) for major depression. The authors conducted a multicenter randomized, controlled trial ... -
The relationship between ADHD and key cognitive phenotypes is not mediated by shared familial effects with IQ
(2011)Background. Twin and sibling studies have identified specific cognitive phenotypes that may mediate the association between genes and the clinical symptoms of attention deficit hyperactivity disorder (ADHD). ADHD is also ... -
Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.
(2014)BACKGROUND: Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal ... -
Repeated insulin-like growth factor 1 treatment in a patient with rett syndrome: a single case study.
(2014)Rett syndrome (RTT) is a devastating neurodevelopmental disorder that has no cure. Patients show regression of acquired skills, motor, and speech impairment, cardio-respiratory distress, microcephaly, and stereotyped hand ... -
Resting-state connectivity deficits associated with impaired inhibitory control in non-treatment-seeking adolescents with psychotic symptoms.
(2014)OBJECTIVE: Psychotic symptoms are common in the population and index risk for a range of severe psychopathological outcomes. We wished to investigate functional connectivity in a community sample of adolescents who ... -
Rett syndrome and Fragile X: different etiology with common molecular dysfunctions
(2021)Rett syndrome (RTT) and Fragile X syndrome (FXS) are two monogenetic neurodevelopmental disorders with complex clinical presentations. RTT is caused by mutations in the Methyl-CpG binding protein 2 gene (MECP2) altering ... -
Rett syndrome in Ireland: a demographic study.
(2024)Background: Rett syndrome (RTT) is a rare neurodevelopmental condition associated with mutations in the gene coding for the methyl-CpG-binding protein 2 (MECP2). It is primarily observed in girls and affects individuals ... -
The role of rare compound heterozygous events in autism spectrum disorder.
(2020)The identification of genetic variants underlying autism spectrum disorders (ASDs) may contribute to a better understanding of their underlying biology. To examine the possible role of a specific type of compound heterozygosity ... -
The Role of Variation at AßPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease.
(2011)Rare mutations in A?PP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of other neurodegenerative disorders. We sought to establish whether ... -
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.
(2012)Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but ... -
Screening for autistic spectrum disorder at the 18-month developmental assessment: a population-based study
(2007)The objectives of this study were to assess the feasibility of administering the CHecklist for Autism in Toddlers (CHAT) at the 18-month developmental check, estimate the prevalence of screening positive for autism at the ... -
Semi-structured Interview of Moral cognitionS (SIMS)
(Trinity College Dublin, School of Medicine, Department of Psychiatry, 2018)This ‘Semi-structured Interview of Moral cognitionS’ (SIMS) is a synthesis of our experience and research in the fields of clinical/forensic psychology and forensic psychiatry. As an interview the SIMS aims to make ... -
Sex representation in neurodegenerative and psychiatric disorders' preclinical and clinical studies
(2023)Many studies show the importance of biological sex for the onset, progression, and response to treatment in brain disorders. In line with these reports, health agencies have requested that all trials, both at the clinical ... -
The SNP ratio test: pathway analysis of genome-wide association datasets
(2009)Summary: We present a tool that assesses the enrichment of significant associations from genome-wide association studies (GWAS) in a pathway context. The SNP ratio test (SRT) compares the proportion of significant to ... -
Social dysfunction in schizophrenia: An investigation of the GAF scale's sensitivity to deficits in social cognition.
(2013)BACKGROUND: Schizophrenia is accompanied by significant impairment in psychosocial functioning, which is only partially explained by clinical symptom severity. Recently, these impairments have been strongly associated ... -
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
(2016)The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter ...