Browsing Psychiatry by Title
Now showing items 312-331 of 434
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Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia.
(2012)With the recent success of genome-wide association studies (GWAS), a wealth of association data has been accomplished for more than 200 complex diseases/traits, proposing a strong demand for data integration and interpretation. ... -
Neural correlates of treatment outcome in major depression.
(2011)There is a need to identify clinically useful biomarkers in major depressive disorder (MDD). In this context the functional connectivity of the orbitofrontal cortex (OFC) to other areas of the affect regulation circuit is ... -
Neuro-developmental Disorders with Co-Morbid Affective Disorders Sometimes Produce Psychiatric Conditions Traditionally Diagnosed as Schizophrenia
(2013)The knowledge in psychiatric genetics, neuroanatomy, functional neuroanatomy, neuropsychology, neuropsychopharmacology and clinical psychiatry, has immensely increased in the last decades. h ere, the psychiatric ... -
Neurocognitive changes in associative- and working memory with aging
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2010)This thesis sought to determine the nature of associative- and working memory dechne during adulthood, and to try and elucidate some of the factors which contribute to this age- related mnemonic decline. In the first study ... -
Neuroimaging to Assess Neonatal Brain Development and Brain Injury in Neonatal Encephalopathy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Neonatal encephalopathy (NE) is a clinical syndrome describing perinatal brain injury and neurological dysfunction in the term-born infant. Magnetic resonance imaging (MRI) is a widely used tool in the assessment of NE, ... -
The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity.
(2001)The neuronal adaptor protein X11a participates in the formation of multiprotein complexes and intracellular trafficking. It contains a series of discrete protein-protein interaction domains including two contiguous ... -
Neuronal cell adhesion genes: key players in risk for schizophrenia, bipolar disorder and other neurodevelopmental brain disorders?
(2010)The major mental disorders, schizophrenia and bipolar disorder are substantially heritable. Recent genomic studies have identified a small number of common and rare risk genes contributing to both disorders and support ... -
Neuropsychosocial predictors of outcomes in opioid dependent patients post-detoxification
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)The current treatment of choice for most opiate dependent persons is long term substitute prescribing. Detoxification is not an effective stand-alone treatment. Given the weak evidence base for detoxification coupled with ... -
New data and an old puzzle: The negative association between schizophrenia and rheumatoid arthritis
(2015)Background: A long-standing epidemiological puzzle is the reduced rate of rheumatoid arthritis (RA) in those with schizophrenia (SZ) and vice versa. Traditional epidemiological approaches to determine if this negative ... -
No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset
(2014)Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present ... -
No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer???s disease
(2019)Introduction: The earliest changes in the brain due to Alzheimer’s disease are associated with the neural networks related to memory function. We investigated changes in functional and structural connectivity among ... -
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
(2016)It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects ... -
A NOS1 variant implicated in cognitive performance influences evoked neural responses during a hight density EEG study of early visual perception.
(Wiley Open Access, 2012)Background: The nitric oxide synthasase‐1 gene (NOS1) has been implicated in mental disorders including schizophrenia and variation in cognition. The NOS1 variant rs6490121 identified in a genome wide association study of ... -
The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals
(Elsevier, 2012)A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated ... -
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.
(2012)Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and ...
