Browsing Psychiatry by Title
Now showing items 242-261 of 434
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Implications of cortical structure and connectivity in autism spectrum disorder
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by early-onset deficits in social communication and interaction together with recurrent restricted repetitive behaviours (APA, 2013). Insights ... -
The importance of cognitive deficits for forensic mental health patients with schizophrenia or schizoaffective disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Forensic Mental Health Services (FMHS) provide care and treatment to a minority of people with mental illness like schizophrenia or schizoaffective disorder, who come into contact with law enforcement agencies (Kennedy et ... -
In God we trust? Organised religion and personal beliefs as resources and coping strategies, and their implications for health in parents with a child on the autistic spectrum
(1999)This paper is part of a larger study looking at the impact on 60 families of having a child with autistic spectrum disorder. Here the roles played by organised reliagion and personal belief and their relationship with ... -
India's Mental Healthcare Act, 2017 Evaluation of the Act, its Context and Initial Implementation
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)The United Nations has initiated a paradigmatic shift in mental healthcare through the United Nations Convention on the Rights of Persons with Disabilities (CRPD), in addition to this the WHO has identified legislation as ... -
Individual common variants exert weak effects on the risk for autism spectrum disorderspi.
(2012)While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To ... -
Inferring the model and onset of natural selection under varying population size from the site frequency spectrum and haplotype structure
(2019)A fundamental question about adaptation in a population is the time of onset of the selective pressure acting on beneficial alleles. Inferring this time, in turn, depends on the selection model. We develop a framework of ... -
Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders
Second generation antipsychotics (SGAs) are used in children and adolescents to treat psychotic symptoms in Early Onset Psychosis (EOP) and irritability and behaviours that challenge in autism spectrum disorder (ASD). ... -
Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects.
(2009)Background: Human and animal studies have implicated the gene NOS1 in both cognition and schizophrenia susceptibility. Objectives: To investigate whether a potential schizophrenia risk SNP (rs6490121) identified in a recent ... -
Interferon-alpha-induced cognitive and affective impairments : contributions of prefrontal cortex and hippocampal formation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Interferon-alpha (IFN-a) is a potent antiviral agent useful in the treatment of many malignancies, but most widely used in the treatment of Hepatitis C. However, sinister adverse events appear as a consequence of ... -
Interplay Between Childhood Physical Abuse and Familial Risk in the Onset of Psychotic Disorders.
(2014)Background : Childhood abuse is considered one of the main environmental risk factors for the development of psychotic symptoms and disorders. However, this association could be due to genetic factors influencing ... -
Inversion effects in the perception of the moving human form - A comparison of adolescents with autism spectrum disorder and typically developing adolescents
(2013)The “body inversion effect” refers to superior recognition of upright than inverted images of the human body and indicates typical configural processing. Previous research by Reed et al. using static images of the human ... -
Investigating clinically relevant phenotypes of neurodevelopmental copy number variants in Children and Adults
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2021)Background: Neurodevelopmental copy number variants (ND CNVs) present with clinically pleiotropic effects, transcending psychiatric diagnostic borders. Gaining clarity on the neurodevelopmental and psychiatric phenotypic ... -
Investigating risk factors and clinical correlates of copy number variants in Autism Spectrum Disorders and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism Spectrum Disorders (ASD) (OMIM 209850) and schizophrenia (OMIM 181510) are both complex neurodevelopmental disorders with extensive emotional and physical costs. Although there has been some progress in understanding ... -
Investigating the effects of schizophrenia genome-wide associated variants on white matter microstructure and brain morphology using diffusion tenson imaging and quantitative MRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)This thesis describes four studies that aim to to elucidate the effects of schizophrenia genome-wide associated variants on measures of white matter microstructure, cortical thickness, surface area and subcortical volume. ...