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dc.contributor.authorCARBALLEDO, ANGELAen
dc.contributor.authorFRODL, THOMASen
dc.contributor.authorFAGAN, ANDREWen
dc.contributor.authorLISIECKA, DANUTAen
dc.contributor.authorMEANEY, JAMESen
dc.contributor.authorKELLEHER, DERMOTen
dc.date.accessioned2010-08-30T11:40:05Z
dc.date.available2010-08-30T11:40:05Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationThomas Frodl, Yolande Ferguson, Andrew Fagan, Danusia Lisiecka, Angela Carballedo, Ian Daly, James Meaney & Dermot Kelleher, Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms?, 2010en
dc.identifier.otherNen
dc.identifier.urihttp://hdl.handle.net/2262/40589
dc.descriptionIN_PRESSen
dc.description.abstractMental disorders are a major cause of long-term disability and are a direct cause of mortality, with approximately 800.000 individuals dying from suicide every year worldwide ? a high proportion of them related to major depressive disorder (MDD)1. Healthy relatives of patients with major depressive disorder (MDD) are at risk to develop the disease. This higher vulnerability is associated with structural2-4 and functional brain changes5. However, we found using high angular resolution diffusion imaging (HARDI) with 61 diffusion directions that neuron tracts between frontal cortices and limbic as well as temporal and parietal brain regions are characterized by better diffusion coefficients in unaffected relatives (UHR), who managed to stay healthy, compared to healthy volunteers without any family history for a psychiatric disease (HC). Moreover, those UHR with stronger fibre connections better managed incidences of adversity in early life without later developing depression, while in HC axonal connections were found to be decreased when they had early-life adversity. Altogether these findings indicate the presence of stronger neural fibre connections in UHR, which seem to be associated with resilience against environmental stressors, which we suggest occur through epigenetic mechanisms.en
dc.description.sponsorshipProfessor Frodl received a Stokes Professorship award from Science Foundation Ireland (SFI) to carry out these investigations.en
dc.language.isoenen
dc.rightsYen
dc.subjectPsychiatryen
dc.subjectmajor depressive disorder (MDD)en
dc.subjectneuroimagingen
dc.titleMicrostructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms?en
dc.typeWorking Paperen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/frodlten
dc.identifier.peoplefinderurlhttp://people.tcd.ie/jmeaneyen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/fagananen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/carbalaen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kellehdpen
dc.identifier.rssinternalid68153en
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDThemeNeuroscienceen
dc.identifier.rssurihttp://hdl.handle.net/10101/npre.2010.4793.1en


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