| dc.contributor.author | WOLFE, KENNETH | en |
| dc.date.accessioned | 2010-08-18T12:05:59Z | |
| dc.date.available | 2010-08-18T12:05:59Z | |
| dc.date.issued | 2002 | en |
| dc.date.submitted | 2002 | en |
| dc.identifier.citation | Coghlan, A., Wolfe, K.H., Fourfold faster rate of genome rearrangement in nematodes than in Drosophila , Genome Research, 12, 6, 2002, 857 - 867 | en |
| dc.identifier.other | Y | en |
| dc.identifier.uri | http://hdl.handle.net/2262/40535 | |
| dc.description | PUBLISHED | en |
| dc.description.abstract | We compared the genome of the nematode Caenorhabditis elegans to 13% of that of Caenorhabditis briggsae, identifying 252 conserved segments along their chromosomes. We detected 517 chromosomal rearrangements, with the ratio of translocations to inversions to transpositions being ~1:1:2. We estimate that the species diverged 50?120 million years ago, and that since then there have been 4030 rearrangements between their whole genomes. Our estimate of the rearrangement rate, 0.4?1.0 chromosomal breakages/Mb per Myr, is at least four times that of Drosophila, which was previously reported to be the fastest rate among eukaryotes. The breakpoints of translocations are strongly associated with dispersed repeats and gene family members in the C. elegansgenome. | en |
| dc.description.sponsorship | We thank the Genome Sequencing Center, Washington University
School of Medicine, St. Louis for allowing us to use
DNA sequence data before publication. This work was supported
by Enterprise Ireland and Science Foundation Ireland.
Many thanks to Karsten Hokamp, Simon Wong, and Cathal
Seoighe for useful discussions and advice. A special thanks to
Aoife McLysaght for help with the Takezaki method, and to
Andrew Lloyd, Noel O?Boyle, Richard Durbin, and three
anonymous reviewers for critical reading of the manuscript.
The publication costs of this article were defrayed in part
by payment of page charges. This article must therefore be
hereby marked ?advertisement? in accordance with 18 USC
section 1734 solely to indicate this fact. | en |
| dc.format.extent | 857 | en |
| dc.format.extent | 867 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Genome Research | en |
| dc.relation.ispartofseries | 12 | en |
| dc.relation.ispartofseries | 6 | en |
| dc.rights | Y | en |
| dc.subject | Genetics | en |
| dc.subject | Caenorhabditis elegans | en |
| dc.subject | Caenorhabditis briggsae | en |
| dc.title | Fourfold faster rate of genome rearrangement in nematodes than in Drosophila | en |
| dc.type | Journal Article | en |
| dc.contributor.sponsor | Science Foundation Ireland | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/khwolfe | en |
| dc.identifier.rssinternalid | 6211 | en |
| dc.identifier.rssuri | http://dx.doi.org/10.1101/gr.172702 | en |
