dc.contributor.author | GILL, MICHAEL | en |
dc.contributor.author | MCCARRON, MARY | en |
dc.contributor.author | HAWI, ZIARIH | en |
dc.contributor.author | FITZGERALD, MICHAEL | en |
dc.date.accessioned | 2010-01-26T16:50:10Z | |
dc.date.available | 2010-01-26T16:50:10Z | |
dc.date.issued | 2001 | en |
dc.date.submitted | 2001 | en |
dc.identifier.citation | Z. Hawi, D. Foley, A. Kirley, M. McCarron, M. Fitzgerald and M. Gill, Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population, Molecular Psychiatry, 6, 4, 2001, 420 - 424 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/36368 | |
dc.description | PUBLISHED | en |
dc.description | (264) PMID: 11443526 ABSTRACT:Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin. Both catecholamines are major neurotransmitters of the mammalian nervous system. It has been suggested that genes involved in the dopaminergic system play a primary role in predisposing to attention deficit hyperactivity disorder (ADHD). In this study, the 4-bp insertion/deletion variant mapped to the first neuronally expressed exon 1 at the dopa decarboxylase gene and two microsatellite markers flanking the gene were investigated for possible association with ADHD. Using HHRR, we observed an increased transmission (though not significant) of the 4-bp insertion (allele 1) to ADHD cases (chi(2) = 2.72, P = 0.1, RR = 1.25). However marginally significant excess transmission of allele 10 (213 bp) of the 3' microsatellite D7S2422 ( approximately 0.75 cM distal to dopa decarboxylase gene) was found (chi(2) = 4.2, P = 0.04, RR=1.48). Interestingly, a haplotype containing both alleles is transmitted more frequently (chi(2)= 5, P = 0.025). Analysing data by the sex of transmitting parent showed a greater relative risk for paternal transmission of the 4-bp insertion allele and allele 10 of the D7S2422 (RR = 1.48 and 1.63 respectively). This provides preliminary evidence that this locus or a closely mapped DNA variant may be involved in the genetic susceptibility to ADHD. However, further studies are required to either confirm or refute these observations. | en |
dc.description.abstract | Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin. Both catecholamines are major neurotransmitters of the mammalian nervous system. It has been suggested that genes involved in the dopaminergic system play a primary role in predisposing to attention deficit hyperactivity disorder (ADHD). In this study, the 4-bp insertion/deletion variant mapped to the first neuronally expressed exon 1 at the dopa decarboxylase gene and two microsatellite markers flanking the gene were investigated for possible association with ADHD. Using HHRR, we observed an increased transmission (though not significant) of the 4-bp insertion (allele 1) to ADHD cases (chi2 = 2.72, P = 0.1, RR = 1.25). However marginally significant excess transmission of allele 10 (213 bp) of the 3' microsatellite D7S2422 (~0.75 cM distal to dopa decarboxylase gene) was found (chi2 = 4.2, P = 0.04, RR=1.48). Interestingly, a haplotype containing both alleles is transmitted more frequently (chi2= 5, P = 0.025). Analysing data by the sex of transmitting parent showed a greater relative risk for paternal transmission of the 4-bp insertion allele and allele 10 of the D7S2422 (RR = 1.48 and 1.63 respectively). This provides preliminary evidence that this locus or a closely mapped DNA variant may be involved in the genetic susceptibility to ADHD. However, further studies are required to either confirm or refute these observations. | en |
dc.description.sponsorship | Health Research Board | en |
dc.format.extent | 420 | en |
dc.format.extent | 424 | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.relation.ispartofseries | Molecular Psychiatry | en |
dc.relation.ispartofseries | 6 | en |
dc.relation.ispartofseries | 4 | en |
dc.rights | Y | en |
dc.subject | attention deficit hyperactivity disorder (ADHD) | en |
dc.subject | dopamine | en |
dc.subject | dopa decarboxylase | en |
dc.subject | association | en |
dc.subject | haplotype based haplotype relative risk (HHRR) | en |
dc.title | Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population | en |
dc.type | Journal Article | en |
dc.contributor.sponsor | Health Research Board (HRB) | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mgill | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mifitzge | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/zhhawi | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mccarrm | en |
dc.identifier.rssinternalid | 21246 | en |
dc.identifier.doi | http://dx.doi.org/10.1038/sj.mp.4000903 | en |
dc.subject.TCDTheme | Neuroscience | en |
dc.subject.TCDTag | ADD/ADHD | en |
dc.subject.TCDTag | ADD/ADHD | en |
dc.subject.TCDTag | ADHD | en |
dc.subject.TCDTag | ADHD | en |
dc.subject.TCDTag | ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) | en |
dc.subject.TCDTag | Adolescent Psychiatry | en |
dc.subject.TCDTag | Attention Deficit Hyperactivity Disorder (ADHD) | en |
dc.subject.TCDTag | CHILD PSYCHIATRY | en |
dc.subject.TCDTag | COMMUNITY PSYCHIATRY | en |
dc.subject.TCDTag | CONSULTATION LIAISON PSYCHIATRY | en |
dc.subject.TCDTag | CONSULTATION-LIAISON PSYCHIATRY | en |
dc.subject.TCDTag | DISORDER ADHD | en |
dc.subject.TCDTag | DOPA DECARBOXYLASE | en |
dc.subject.TCDTag | Dopa decarboxylase gene polymorphisms | en |
dc.subject.TCDTag | GENE POLYMORPHISM | en |
dc.subject.TCDTag | GENE POLYMORPHISMS | en |
dc.subject.TCDTag | GENERAL HOSPITAL PSYCHIATRY | en |
dc.subject.TCDTag | LIAISON PSYCHIATRY | en |
dc.subject.TCDTag | Neuropsychiatry | en |
dc.subject.TCDTag | Neuropsychiatry | en |
dc.subject.TCDTag | PSYCHIATRY | en |
dc.subject.TCDTag | Psychiatry | en |
dc.subject.TCDTag | Psychiatry | en |
dc.subject.TCDTag | TRAINEES IN PSYCHIATRY | en |
dc.subject.TCDTag | child and adolescent Psychiatry | en |
dc.subject.TCDTag | neurodevelopmental psychiatry | en |
dc.identifier.rssuri | http://professormichaelfitzgerald.eu/ | en |
dc.identifier.rssuri | http://www.nature.com/mp/journal/v6/n4/full/4000903a.html | en |
dc.identifier.rssuri | http://www.ncbi.nlm.nih.gov/pubmed/11443526 | en |