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The effect of mobile element IS10 on experimental regulatory evolution in Escherichia coli
(2010)
Mobile genetic elements are widespread in bacteria, where they cause several kinds of mutations. Although their effects are on the whole negative, rare beneficial mutations caused by insertion sequence elements are frequently ...
H-NS silences gfp, the Green Fluorescent Protein gene: gfpTCD is a genetically remastered gfp gene with reduced susceptibility to H-NS-mediated transcription silencing and with enhanced translation
(2010)
The bacterial nucleoid-associated protein H-NS, which preferentially targets and silences A+T-rich genes, binds the ubiquitous reporter gene gfp and dramatically reduces local transcription. We have redesigned gfp to reduce ...
A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila
(2010)
Techniques to induce activity-dependent neuronal plasticity in vivo allow the underlying signaling pathways to be studied in their biological context. Here, we demonstrate activity-induced plasticity at neuromuscular ...
Ohnologs in the human genome are dosage balanced and frequently associated with disease
(2010)
About 30% of protein-coding genes in the human genome are
related through two whole genome duplication (WGD) events.
Although WGD is often credited with great evolutionary importance,
the processes governing the retention ...
Localized hypermutation and associated gene losses in legume chloroplast genomes
(2010)
Point mutations result from errors made during DNA replication or repair, so they are usually expected to be homogeneous across all regions of a genome. However, we have found a region of chloroplast DNA in plants related ...
Mutational dynamics of murine angiogenin duplicates
(2010)
Background: Angiogenin (Ang) is a protein involved in angiogenesis by inducing the formation of blood vessels.
The biomedical importance of this protein has come from findings linking mutations in Ang to cancer progression
and ...
Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90)
(2010)
Retinitis pigmentosa (RP) is the most prevalent cause of registered visual handicap among working aged populations of developed countries. Up to 40% of autosomal dominant cases of disease are caused by mutations within the ...
Duplicability of self-interacting human genes.
(2010)
Background: There is increasing interest in the evolution of protein-protein interactions because this should ultimately be informative of the patterns of evolution of new protein functions within the cell. One model ...
Mitochondrial fission/fusion dynamics and apoptosis
(2010)
Mitochondria play an important role in the progression of apoptosis through the release of pro-apoptotic factors, such as cytochrome c, from the mitochondrial intermembrane space. During this process, mitochondrial networks ...