Browsing School of Genetics & Microbiology by Title
Now showing items 464-483 of 872
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Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans.
(2008)Staphylococcus aureus permanently colonizes the vestibulum nasi of one-fifth of the human population, which is a risk factor for autoinfection. The precise mechanisms whereby S. aureus colonizes the nose are still unknown. ... -
Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives
(2022)In recent decades, probiotic bacteria have become increasingly popular as a result of mounting scientific evidence to indicate their beneficial role in modulating human health. Although there is strong evidence associating ... -
A letter from William B. Brownrigg to Thomas H. Huxley, dated 29 November 1865, authorising him to describe his fossil vertebrates from Jarrow Colliery, Co. Kilkenny and giving details of his find
(2011)William Bookey Brownrigg, who discovered the Upper Carboniferous (Pennsylvanian) vertebrate fossils at Jarrow Colliery, Co. Kilkenny in 1864, published a short paper on the material. Shortly afterwards E.P. Wright, a ... -
LineUp: Statistical Detection of Chromosomal Homology with Application to Plant Comparative Genomics
(2003)The identification of homologous regions between chromosomes forms the basis for studies of genome organization, comparative genomics, and evolutionary genomics. Identification of these regions can be based on either synteny ... -
Localized hypermutation and associated gene losses in legume chloroplast genomes
(2010)Point mutations result from errors made during DNA replication or repair, so they are usually expected to be homogeneous across all regions of a genome. However, we have found a region of chloroplast DNA in plants related ... -
Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis.
(2018)Background and aims: microRNAs regulate gene expression and influence the pathogenesis of human diseases. The present study investigated the role of microRNA-21 [miR-21] in the pathogenesis of intestinal inflammation, ... -
Macrosynteny analysis shows the absence of ancient whole-genome duplication in lepidopteran insects
(2019)Whole-genome duplication (WGD) is considered a key evolutionary event for genetic innovation and has occurred in diverse eukaryotic lineages (1). In PNAS, Li et al. (2) report multiple WGD events in hexapods, which is ... -
Mammalian X chromosome inactivation evolved as a dosage-compensation mechanism for dosage-sensitive genes on the X chromosome.
(2012)How and why female somatic X-chromosome inactivation (XCI) evolved in mammals remains poorly understood. Ohno proposed a two-step process where XCI is a dosage-compensation mechaQ: 7 nism that evolved to equalize ... -
MDMA "ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI
(2013)BACKGROUND AND PURPOSE: The purpose of this study was to assess cerebral perfusion changes following systemic administration of the recreational drug 3,4-methylendioxymethamphetamine (MDMA 'ecstasy') to rats. EXPERIMENTAL ... -
Mechanical strength and inhibition of the Staphylococcus aureus collagen-binding protein Cna
(2016)The bacterial pathogen Staphylococcus aureus expresses a variety of cell surface adhesion proteins that bind to host extracellular matrix proteins. Among these, the collagen (Cn)-binding protein Cna plays important roles ... -
Mechanisms of action and vulnerabilities associated with the oncogene EZH2 in germinal centre B-cell non-Hodgkin lymphoma
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Polycomb group (PcG) proteins are highly conserved chromatin regulators that play a critical role as transcriptional repressors in mediating and maintaining cellular identity. PcG proteins assemble into large, distinct, ... -
Mechanisms of Chromosome Number Evolution in Yeast
(PLoS, 2011)The whole-genome duplication (WGD) that occurred during yeast evolution changed the basal number of chromosomes from 8 to 16. However, the number of chromosomes in post-WGD species now ranges between 10 and 16, and the ... -
Meta-Analysis of mitochondrial DNA reveals several population bottlenecks during worldwide migrations of cattle
(2014)Several studies have investigated the differentiation of mitochondrial DNA in Eurasian, African and American cattle as well as archaeological bovine material. A global survey of these studies shows that haplogroup distributions ...
