Browsing School of Genetics & Microbiology by Title
Now showing items 200-219 of 870
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Early farmers from across Europe directly descended from Neolithic Aegeans
(2016)One of the most enduring and widely debated questions in prehistoric archaeology concerns the origins of Europe’s earliest farmers: Were they the descendants of local hunter-gatherers, or did they migrate from southwestern ... -
Ecological dependencies and the illusion of cooperation in microbial communities
(2024)Ecological dependencies - where organisms rely on other organisms for survival - are a ubiquitous feature of life on earth. Multicellular hosts rely on symbionts to provide essential vitamins and amino acids. Legume plants ... -
Ecological selection of siderophore-producing microbial taxa in response to heavy metal contamination
(2018)Some microbial public goods can provide both individual and community-wide benefits, and are open to exploitation by non-producing species. One such example is the production of metaldetoxifying siderophores. Here, we ... -
The effect of chaperonin buffering on protein evolution.
(2010)Molecular chaperones are highly conserved and ubiquitous proteins that help other proteins in the cell to fold. Pioneering work by Rutherford and Lindquist suggested that the chaperone Hsp90 could buffer (that is, suppress) ... -
Effect of gene structure changes on the rate of protein sequence evolution
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)The elaborate architecture of the genes of niulticellular eukaryotes is likely to underpin the unique complexity of eukaryotic gene functions. The structure of eukaryotic genes differs from that of prokaryotes and represents ... -
Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-? on the progression of experimental autoimmune encephalomyelitis.
(Spandidos, 2008)The effect of intranasal (IN) administration of Semliki Forest virus (SFV) recombinant particles expressing interferon-? [IFN-?, a partially effective treatment for multiple sclerosis (MS)] on the progression of experimental ... -
Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-beta on the progression of experimental autoimmune encephalomyelitis
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Multiple sclerosis (MS) is an autoimmune demyelinating disease of the CNS, characterized by the presence of sclerotic lesions throughout the brain. MS is thought to be a CD4+ T helper 1 disease caused by the infiltration ... -
The effect of mobile element IS10 on experimental regulatory evolution in Escherichia coli
(2010)Mobile genetic elements are widespread in bacteria, where they cause several kinds of mutations. Although their effects are on the whole negative, rare beneficial mutations caused by insertion sequence elements are frequently ... -
Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus
(2012)Recombinant adeno-associated virus (AAV) represents an efficient system for neuronal transduction. However, a potential drawback of AAV is its restricted packaging capacity of approximately 5kb. To bypass this limita- tion, ... -
Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho?^'/?^' mouse
(Elsevier, 2015)As gene therapies for various forms of retinal degeneration progress toward human clinical trial, it will be essential to have a repertoire of safe and efficient vectors for gene delivery to the target cells. Recombinant ... -
Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice
(2015)Mouse full-field electroretinograms (ERGs) are dominated by responses of photoreceptors and depolarizing (ON-) bipolar cells, but not much of hyperpolarizing (OFF-) bipolar cells under conventional recording conditions. ... -
Elusive origins of the extra genes in Aspergillus oryzae
(PLoS, 2008)The genome sequence of Aspergillus oryzae revealed unexpectedly that this species has approximately 20% more genes than its congeneric species A. nidulans and A. fumigatus. Where did these extra genes come from? Here, we ... -
Emergence of the Epidemic Methicillin-Resistant Staphylococcus aureus Strain USA300 Coincides with Horizontal Transfer of the Arginine Catabolic Mobile Element and speG-mediated Adaptations for Survival on Skin.
(2013)The arginine catabolic mobile element (ACME) is the largest genomic region distinguishing epidemic USA300 strains of methicillin-resistant Staphylococcus aureus (MRSA) from other S. aureus strains. However, the functional ... -
Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis.
(2009)Summary Bcl-2 family proteins regulate apoptosis by controlling the release of mitochondrial cytochrome c via the Bax/Bak channel. However, recent studies have also implicated several members of this family in the regulation ... -
Engineering Saccharomyces pastorianus for the co-utilisation of xylose and cellulose from biomass.
(2015)Background Lignocellulosic biomass is a viable source of renewable energy for bioethanol production. For the efficient conversion of biomass into bioethanol, it is essential that sugars from both the cellulose and ... -
Enhancement of outflow facility in the murine eye by targeting selected tight-junctions of Schlemm's canal endothelia
(2017)The juxtacanalicular connective tissue of the trabecular meshwork together with inner wall endothelium of Schlemm’s canal (SC) provide the bulk of resistance to aqueous outflow from the anterior chamber. Endothelial cells ... -
Epidemiology of Streptococcus agalactiae (Group B Streptococci) in Dublin Maternity Hospitals
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Streptococcus agalactiae (Group B Streptococci) are Gram-positive encapsulated cocci distinguished from other streptococci by their narrower zones of P-haemolysis. Group B Streptococci (GBS) was first described as an ...