Browsing School of Genetics & Microbiology by Title
Now showing items 455-474 of 876
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Investigations on apoptosis-associated caspase activation cascades
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)Apoptosis is an important process in a wide variety of different biological systems such as the immune system, normal cell turnover and embryonic development (Stennicke et al., 2002). Apoptosis is characterized by a series ... -
Involvement of the accessory gene regulator (agr) in expression of type 5 capsular polysaccharide by Staphylococcus aureus
(1993)The effect of an agr mutation on expression of type 5 capsular polysaccharide (CP) by Staphylococcus aureus Newman was investigated in different complex and synthetic media. CP expression by the agr mutant was strongly ... -
Iron regulated surface determinants of Staphylococcus aureus and S. lugdunensis : their roles in pathogen-host interactions
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)Staphylococcus aureus is a human pathogen that causes invasive infections. The ability to internalize into and persist within host cells is thought to contribute to pathogenesis. The study described here has identified a ... -
ITap, a novel irhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
(eLife Sciences Publications, 2018)The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves ... -
John Tyndall: Peaks and troughs.
(2013-07-01)The scientist and natural philosopher John Tyndall was known to the public through his lectures and newspaper debates. But, say Miguel DeArce and Norman MacMillan, one of Tyndall?s most famous public speeches, his ... -
Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans.
(2008)Staphylococcus aureus permanently colonizes the vestibulum nasi of one-fifth of the human population, which is a risk factor for autoinfection. The precise mechanisms whereby S. aureus colonizes the nose are still unknown. ... -
Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives
(2022)In recent decades, probiotic bacteria have become increasingly popular as a result of mounting scientific evidence to indicate their beneficial role in modulating human health. Although there is strong evidence associating ... -
A letter from William B. Brownrigg to Thomas H. Huxley, dated 29 November 1865, authorising him to describe his fossil vertebrates from Jarrow Colliery, Co. Kilkenny and giving details of his find
(2011)William Bookey Brownrigg, who discovered the Upper Carboniferous (Pennsylvanian) vertebrate fossils at Jarrow Colliery, Co. Kilkenny in 1864, published a short paper on the material. Shortly afterwards E.P. Wright, a ... -
LineUp: Statistical Detection of Chromosomal Homology with Application to Plant Comparative Genomics
(2003)The identification of homologous regions between chromosomes forms the basis for studies of genome organization, comparative genomics, and evolutionary genomics. Identification of these regions can be based on either synteny ... -
Localized hypermutation and associated gene losses in legume chloroplast genomes
(2010)Point mutations result from errors made during DNA replication or repair, so they are usually expected to be homogeneous across all regions of a genome. However, we have found a region of chloroplast DNA in plants related ... -
Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis.
(2018)Background and aims: microRNAs regulate gene expression and influence the pathogenesis of human diseases. The present study investigated the role of microRNA-21 [miR-21] in the pathogenesis of intestinal inflammation, ...