Browsing School of Genetics & Microbiology by Title
Now showing items 288-307 of 873
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Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma
(2021)Previous studies have shown that glaucomatous Schlemm’s canal endothelial cells (gSCECs) are stiffer and associated with reduced porosity and increased extracellular matrix (ECM) material compared to SCECs from healthy ... -
Fluid Gels: a New Feedstock for High Viscosity Jetting
(2018)Suspensions of gel particles which are pourable or spoonable at room temperature can be created by shearing a gelling biopolymer through its gelation (thermal or ion mediated) rather than allowing quiescent cooling – thus ... -
Fly model causes neurological rethink
(2013)A Drosophila model for a neurological disorder called type 2B Charcot- Marie-Tooth disease reveals that it has its origins in a partial loss of function, rather than a gain of function, which points to the need for ... -
FNR is a regulator of Salmonella pathogenicity Island 2 in Salmonella Typhimurium
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2019)During infection, S. Typhimurium employs Salmonella pathogenicity island (SPI)-encoded type three secretion systems (T3SS) 1 and 2 to invade and survive in host cells. However, expression of SPI-2 is seen at the epithelial ... -
Following the genes: a framework for animal modeling of psychiatric disorders.
(2011)The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models ... -
Fourfold faster rate of genome rearrangement in nematodes than in Drosophila
(2002)We compared the genome of the nematode Caenorhabditis elegans to 13% of that of Caenorhabditis briggsae, identifying 252 conserved segments along their chromosomes. We detected 517 chromosomal rearrangements, with the ratio ... -
From single nucleotide polymorphisms to high-throughput sequencing in the complex genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive weakening of limb and bulbar muscles resulting in paralysis and death from respiratory failure within three to five years ... -
Function and evolution of genes in the human protein interaction network
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)The research conducted for this thesis aims to elucidate how the human protein interaction network has evolved, and how protein interactions influence the spatial organisation of the metabolic network. The thesis presents ... -
Functional analyses of a novel leucine-rich repeat-containing protein, Elfn1, in the mouse
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)The functional brain is critically dependent on a highly specific and perfectly timed gene-expression programme that underlies neuronal connectivity. Each step of this process, which includes cell migration, axon guidance, ... -
Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus.
(2010)Fibronectin-binding proteins A and B are multifunctional LPXTG staphylococcal adhesins, comprising an N-terminal region that binds fibrinogen and elastin, and a C-terminal domain that interacts with fibronectin. The ... -
Functional analysis of a novel transmembrane protein, P1xdc2, in the developing nervous system of the chick and mouse
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)Studies utilising the PLAP secretory trap method isolated a gene trap insertion in a novel gene (mouse line KST37) (Leighton et al., 2001) which has since been named Plexin domain containing 2 (Plxdc2). Plxdc2 encodes a ... -
Functional assessment of non-coding regulatory variants in familial breast cancer
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)Breast cancer is the most common cancer in Irish women, with almost 3,000 cases diagnosed every year. It often runs in families, and some women inherit a greater risk of developing the disease. Landmark studies on these ... -
Functional characterisation of Arabidopsis genes encoding members of the AP2/ERF transcription factor family
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)The EU Framework 5 REGIA (Regulatory Gene Initiative in Arabidopsis) Consortium, comprising 29 laboratories, was established to investigate transcription factor gene function in Arabidopsis. As part of the REGIA project, ... -
Functional characterisation of small RNAs in Acinetobacter baumannii using Hi-GRIL-seq
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2021)Acinetobacter baumannii is a priority pathogen that is a leading source of nosocomial multidrug resistant (MDR) infections worldwide. A key to the success of A. baumannii is the ability to quickly adapt to changing ... -
Functional conservation of an ancestral Pellino protein in helminth species
(2015)The immune system of H. sapiens has innate signaling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms such as ... -
Functional Diversification of the Twin-Arginine Translocation Pathway Mediates the Emergence of Novel Ecological Adaptations
(2011)Microorganisms occupy a myriad of ecological niches that show an astonishing diversity. The molecular mechanisms underlying microbes? ecological diversity remain a fundamental conundrum in evolutionary biology. Evidence ... -
Functional Partitioning of Yeast Co-Expression Networks after Genome Duplication
(Public Library of Science, 2006)Several species of yeast, including the baker?s yeast Saccharomyces cerevisiae, underwent a genome duplication roughly 100 million years ago. We analyze genetic networks whose members were involved in this duplication. ... -
A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2
(2012)DNA topology has fundamental control over the ability of transcription factors to access their target DNA sites at gene promoters. However, the influence of DNA topology on protein–DNA and protein–protein interactions is ... -
Fundus Fluorescein Angiography (FFA) in Human Subjects Displays Circadian Variation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)The relationship between retinal inner blood-retina barrier (iBRB) permeability, the circadian clock and their possible role in retinal pathology is unknown. We performed quantitative fundus fluorescein angiography (FFA) ...