Browsing Pharmaceutics & Pharmaceutical Technology (Theses and Dissertations) by Title
Now showing items 7-11 of 11
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Potential applications of halloysite for improved topical drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The aim of this thesis was to evaluate the potential application of halloysite, an aluminosilicate clay material, for use in topical and transdermal drug delivery. Halloysite is a tubular material, the hollow lumen has ... -
Potential pharmaceutical applications of sepiolite
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)The focus of the research presented in this thesis was on the potential pharmaceutical applications of sepiolite from the Vallecas-Vicalvaro region in Spain. Initial studies involved extensive characterisation of sepiolite ... -
The use of the Caco-2 cell culture model to investigate lipid vehicle effects on lipid metabolism and drug permeation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)The aim of this thesis was to assess the usefulness of the Caco-2 model for screening lipid vehicle excipient effects on intestinal lipoprotein production and secretion, with emphasis on chylomicron secretion. In addition, ... -
Transdermal delivery of somatostatin analogues
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)The aim of this work was to develop transdermal delivery systems for the administration of two peptidic somatostatin analogues, BIM-23014 and its higher potency analogue BIM-23190. Due to its ability to suppress growth ... -
Use of halloysite for agrochemical applications
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)The focus of this thesis was to develop two products for use in agrochemical applications, using the naturally occurring microtubular mineral, halloysite. Firstly, it was necessary to obtain a highly tubular grade of the ...