Browsing Mechanical & Manufacturing Eng (Scholarly Publications) by Sponsor "Science Foundation Ireland"
Now showing items 1-20 of 20
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3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects
(2020)Successful osteochondral defect repair requires regenerating the subchondral bone whilst simultaneously promoting the development of an overlying layer of articular cartilage that is resistant to vascularization and ... -
Air jet cooling of brake discs
(Institution of Mechanical Engineers, 2008)This paper reports on an investigation of a novel approach to the cooling of brake discs, based on the application of impinging air jets. This has the capacity to enhance the heat transfer coefficients at the disc surface ... -
Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers
(2019)Successful tissue engineering requires the generation of human scale implants that mimic the structure, composition and mechanical properties of native tissues. Here, we report a novel biofabrication strategy that enables ... -
A comparative study of shear stresses in collagen-GAG and calcium phosphate scaffolds in bone tissue-engineering bioreactors
(Mary Ann Liebert, 2008)The increasing demand for bone grafts combined with their limited availability and potential risks has led to much new research in bone tissue engineering. Current strategies of bone tissue engineering commonly utilize ... -
Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model.
(2009)Tissue-engineered bone shows promise in meeting the huge demand for bone grafts caused by up to 4 million bone replacement procedures per year, worldwide. State-of-the-art bone tissue engineering strategies use flow perfusion ... -
A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect
(2020)There is a distinct clinical need for new therapies that provide an effective treatment for large bone defect repair. Herein we describe a developmental approach, whereby constructs are primed to mimic certain aspects of ... -
Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells.
(2008)The objective of this study was to investigate the influence of dynamic compressive loading on chondrogenesis of mesenchymal stem cells (MSCs) in the presence of TGF-?3. Isolated porcine MSCs were suspended in 2% agarose ... -
The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering.
(IOS Press, 2007)The permeability of scaffolds and other three-dimensional constructs used for tissue engineering applications is important as it controls the diffusion of nutrients in and waste out of the scaffold as well as influencing ... -
Facing the Information Leaks in Industrial Water Systems: A Concept for Proxy Measurements to Support Water Metering Audits
(2018)Water optimisation methods and water benchmarking are receiving growing attention in manufacturing surroundings. A basic requirement for any of these approaches is a water metering audit. However, missing ... -
Fiber Reinforced Cartilage ECM Functionalized Bioinks for Functional Cartilage Tissue Engineering
(2019)Focal articular cartilage (AC) defects, if left untreated, can lead to debilitating diseases such as osteoarthritis. While several tissue engineering strategies have been developed to promote cartilage regeneration, it ... -
How context shapes the appropriateness of a robot's voice
(2020)Social robots have a recognizable physical appearance, a distinct voice, and interact with users in specific contexts. Previous research has suggested a 'matching hypothesis', which seeks to rationalise how people judge a ... -
Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells
(2019)Controlling the phenotype of transplanted stem cells is integral to ensuring their therapeutic efficacy. Hypoxia is a known regulator of stem cell fate, the effects of which can be mimicked using hypoxia-inducible factor ... -
Jet heat transfer in the vicinity of a rotating grinding wheel
(Professional Engineering Publishing, 2006)Impinging jets are known as a method of achieving high convective heat transfer coefficients. One potential application of impinging jet heat transfer is the air jet cooling of a grinding process. A grinding process ... -
Measuring and Modeling Oxygen Transport and Consumption in 3D Hydrogels Containing Chondrocytes and Stem Cells of Different Tissue Origins.
(2021)Understanding how the local cellular environment influences cell metabolism, phenotype and matrix synthesis is crucial to engineering functional tissue grafts of a clinically relevant scale. The objective of this study was ... -
Methacrylated Cartilage ECM-Based Hydrogels as Injectables and Bioinks for Cartilage Tissue Engineering
(2022)Articular cartilage (AC) possesses a limited healing potential, meaning that untreated focal joint defects typically progress, leading to the development of degenerative diseases such as osteoarthritis. Several clinical ... -
Nozzle Geometry Effects in Liquid Jet Array Impingement
(Elsevier, 2009)The use of impinging liquid jets in electronics thermal management is attracting some consideration due to their very high heat transfer coefficients, hot spot targeting capabilities and moderate hydraulic power requirements. ... -
Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues
(2019)The regeneration of complex tissues and organs remains a major clinical challenge. With a view towards bioprinting such tissues, we developed a new class of pore-forming bioink to spatially and temporally control the ... -
A thermal-hydraulic comparison of liquid microchannel and impinging liquid jet array heat sinks for high power electronics cooling
(IEEE, 2009)In this paper, two single-phase liquid cooling strategies for electronics thermal management are compared and contrasted; impinging jet arrays and laminar flow in microchannels. The comparison is posed for a situation ...