Browsing Mechanical & Manufacturing Eng (Scholarly Publications) by Subject "Bioengineering"
Now showing items 1-20 of 36
-
An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue
(2012)Inelastic phenomena such as softening and unrecoverable inelastic strains induced by loading have been observed experimentally in soft tissues such as arteries. These phenomena need to be accounted for in constitutive ... -
Apparent behaviour of charged and neutral materials with ellipsoidal fibre distributions and cross-validation of finite element implementations
(2012)Continuous fibre distribution models can be applied to a variety of biological tissues with both charged and neutral extracellular matrices. In particular, ellipsoidal models have been used to describe the complex material ... -
Biomechanics of the stick insect antenna: Damping properties and structural correlates of the cuticle
(2011)The antenna of the Indian stick insect Carausius morosus is a highly specialized near-range sensory probe used to actively sample tactile cues about location, distance or shape of external objects in real time. The length ... -
Bone tissue material properties are altered during osteoporosis
(Hylonome, 2005)Measurement of the effects of osteoporosis on the mechanical behavior of bone has been performed using whole bone testing, or testing of volumes of ovariectomized cancellous bone1-3 and these studies revealed a decrease ... -
Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure
(2012)Both hydrostatic pressure (HP) and cell-matrix interactions have independently been shown to regulate the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to test the hypothesis ... -
Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad
(2011)The objective of this study was to determine the functional properties of cartilaginous tissues generated by porcine MSCs isolated from different tissue sources, and to compare these properties to those derived from ... -
Computer simulating a clinical trial of a load-bearing implant: example of an intramedullary prosthesis
(2011)Computational modelling is becoming ever more important for obtaining regulatory approval for new medical devices. An accepted approach is to infer performance in a population from an analysis conducted in an idealized or ... -
Defining the impaction frequency and threshold force required for femoral impaction grafting in revision hip arthroplasty. A human cadaveric mechanical study.
(2011)BACKGROUND AND PURPOSE: The two most common complications of femoral impaction bone grafting are femoral fracture and massive implant subsidence. We investigated fracture forces and implant subsidence rates in embalmed ... -
Development of a gait training device for children with cerebral palsy
(2010-04-27)Children with Cerebral Palsy (CP) can generally not walk unaided, but do have some weight bearing ability. Therefore walking aids are often more appropriate than wheelchairs, see figure 1. These devices facilitate mobility ... -
Digital image correlation and finite element modelling as a method to determine mechanical properties of human soft tissue in vivo.
(2009)The mechanical properties of human soft tissue are crucial for impact biomechanics, rehabilitation engineering and surgical simulation. Validation of these constitutive models using human data remains challenging and often ... -
Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint
(University of Edinburgh (datashare), 2011)Muscle contractions begin in early embryonic life, generating forces that regulate the correct formation of the skeleton. In this paper we test the hypothesis that the biophysical stimulation generated by muscle forces may ... -
The effect of a thermal renal denervation cycle on the mechanical properties of the arterial wall
(2014)The aim of this study was to determine the effect that a thermal renal denervation cycle has on the mechanical properties of the arterial wall. Porcine arterial tissue specimens were tested in three groups: native tissue, ... -
The effect of cyclic hydrostatic pressure on the functional development of cartilaginous tissues engineered using bone marrow derived mesenchymal stem cells
(2011)Mechanical signals can play a key role in regulating the chondrogenic differentiation of Mesenchymal Stem Cells (MSCs). The objective of this study was to determine if the long-term application of cyclic hydrostatic pressure ... -
Engineering of large cartilaginous constructs through the use of microchanneled hydrogels and rotational culture
(2009)The development of functional engineered cartilaginous tissues of sufficient size that can be used clinically to treat large defects remains a major and significant challenge. This study investigated if the introduction ... -
Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs
(2012)MSCs from non-cartilaginous knee joint tissues such as the infrapatellar fat pad (IFP) and synovium possess significant chondrogenic potential and provide a readily available and clinically feasible source of chondroprogenitor ... -
The fracture toughness of soft tissues
(2012)Fracture toughness is important for any material, but to date there have been few investigations of this mechanical property in soft mammalian tissues. This paper presents new data on porcine muscle tissue and a detailed ... -
Imaging arterial fibres using diffusion tensor imaging - feasibility study & preliminary results
(2010)MR diffusion tensor imaging (DTI) was used to analyze the fibrous structure of aortic tissue. A fresh porcine aorta was imaged at 7T using a spin echo sequence with the following parameters: matrix 128 ? 128 pixel; slice ... -
In vivo dynamics of the internal fibrous structure in smooth adhesive pads of insects
(2012)Many insects with smooth adhesive pads can rapidly enlarge their contact area by centripetal pulls on the legs, allowing them to cope with sudden mechanical perturbations such as gusts of wind or raindrops. The short time ... -
Low oxygen tension is a more potent promoter of chondrogenic
(2010)During fracture healing and microfracture treatment of cartilage defects mesenchymal stem cells (MSCs) infiltrate the wound site, proliferate extensively and differentiate along a cartilaginous or an osteogenic lineage ...