Browsing Mechanical & Manufacturing Eng (Theses and Dissertations) by Sponsor "European Research Council (ERC)"
Now showing items 1-14 of 14
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3D Bioprinted Cartilaginous Templates as Developmentally Inspired Implants for Large Bone Defect Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Whilst bone possesses an inherent capacity for regeneration, defects above a critical size cannot heal on their own. Damaged or diseased bone can be treated using autografts or a range of different bone grafting biomaterials, ... -
3D bioprinting of cartilage-mimetic implants for biological joint resurfacing
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)A major challenge in the field of tissue engineering and regenerative medicine is the development of effective therapies for treating large cartilage or osteochondral defects and ultimately regenerating whole osteoarthritic ... -
3D Bioprinting of Developmentally Inspired Templates for Bone and Joint Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)There is an urgent need to develop alternatives to synthetic joint prosthesis to promote the regeneration of diseased osteoarthritic joints. Cell based therapies have shown promise for repairing cartilage and bone; however, ... -
Biophysical Regulation of Stem Cell Osteogenic Lineage Commitment: A Role for the Cytoskeleton
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Osteoporosis is a debilitating disease characterised by weakened bone architecture due to increased resorption activity of osteoclasts and diminished bone deposition by mesenchymal stem cell (MSC) derived osteoblasts. ... -
Deciphering the Molecular Mechanisms of Stem Cell Mechanotransduction: A New Avenue for the Development of Therapeutics for Osteoporosis
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Osteoporosis is characterised by reduced bone density and weakened bone architecture leading to high fracture risk. The changes in bone result from an imbalance in the bone remodelling cycle whereby the rate of resorption ... -
Development and characterization of corneal substitutes from decellularized tissues
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Diseases affecting the cornea can lead to vision impairment and ultimately to blindness. It is estimated that 45 million people worldwide suffer from corneal blindness. Rejection in high-risk patients and donor shortage ... -
The Development of a Novel 3D Bioprinting Strategy to Drive Vascularisation, and its Application for Bone Tissue Engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)One of the major challenges facing the field of tissue engineering today is vascularisation. Without a system in place to circulate oxygen, nutrients and metabolites, the size of many tissue engineered constructs is ... -
Development of mechanobiomimetic strategies to drive stem cell behaviour for bone regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)There are a host of cases where clinical intervention must be taken to treat diseased or damaged bone, including severe fractures, defects, tumours requiring tissue removal, and debilitating diseases such as osteoporosis. ... -
Fundamental Insights into Arterial Remodelling; Strain-Mediated Degradation of Arterial Collagen
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Maladaptive remodelling of structurally significant collagen fibres in the arterial wall is believed to play a critical role in the development and progression of degenerative arterial disease. A greater understanding of ... -
Influence of Mechanical Environment on Limbal and Corneal Epithelial Cells
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Corneal blindness is the 4th leading cause of blindness and the most transplanted tissue worldwide. Severe donor shortages and immune rejection has led to research into alternative therapies for corneal transplantation. ... -
Integrating non-viral gene therapy and 3D bioprinting for bone, cartilage and osteochondral tissue engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)The repair of osteochondral defects, affecting both the articular cartilage and the underlying subchondral bone, is key for the effective recovery of joint homeostasis and the prevention of further cartilage degeneration ... -
An investigation into diffusion tensor imaging-derived metrics in arterial tissue as biomarkers for disease progression, plaque rupture and graft recellularisation
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Non-invasive imaging offers great potential for several clinical applications, both in disease and treatment monitoring. Specifically, within vascular tissue better clinical indicators for vulnerable atherosclerotic plaque, ... -
Mechanical Assessment of the Risk of Atherosclerotic Plaque Rupture in Carotid Arteries with a Focus on Damage Accumulation
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Carotid atherosclerotic plaque rupture is one of the leading causes of death. Growth and development of atherosclerotic plaque alters the geometry and mechanical environment of the healthy arterial tissue. Supra-physiological ... -
Spatial presentation of tissue specific extracellular matrix components and growth factors on porous electrospun fibre scaffolds for bone-ligament interface tissue engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)In many clinical situations ligament or tendon replacements are required, such as for the surgical replacement of a torn anterior cruciate ligament (ACL). The current ‘gold standard’ treatment is resection of the torn ...