Browsing Clinical Medicine (Scholarly Publications) by Subject "cancer"
Now showing items 1-3 of 3
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Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising.
(2014)The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell’s genetic material and can lead to genomic ... -
Functions and therapeutic roles of exosomes in cancer.
(2014)The role of exosomes in cancer development has become the focus of much research, due to the many emerging roles possessed by exosomes. These micro-vesicles that are ubiquitously released in to the extracellular milieu, ... -
Targeting nuclear factor-kappa B to overcome resistance to chemotherapy.
(2013)Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug ...