Browsing Clinical Medicine (Scholarly Publications) by Subject "Health"
Now showing items 1-20 of 34
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'Altered Mitochondrial Function and Energy Metabolism Is Associated with a Radioresistant Phenotype in Oesophageal Adenocarcinoma'.
(2014)Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is ... -
Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?
(2018)AIM: To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori (H. pylori)-infected patients in Ireland. METHODS: DNA was extracted from antral and corpus biopsies ... -
Capsule endoscopy with artificial intelligence-assisted technology: Real-world usage of a validated AI model for capsule image review
(2023)Background and study aims Capsule endoscopy is a time-consuming procedure with a significance error rate. Artificial intelligence (AI) can potentially reduce reading time significantly by reducing the number of images ... -
?Changes in mitochondrial stability during the progression of the Barrett?s esophagus sequence?.
(2016)Background: Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis of ... -
Colon capsule endoscopy is a viable alternative to colonoscopy for the investigation of intermediate- and low-risk patients with gastrointestinal symptoms: results of a pilot study
(2021)Background and study aims: Colon capsule endoscopy (CCE) is a recommended viable alternative to colonoscopy for colonic visualisation in a variety of clinical settings with proven efficacy in polyp detection, surveillance, ... -
Comparing Colon Capsule Endoscopy To Colonoscopy; A Symptomatic Patient?s Perspective
(2022)Background Colon Capsule Endoscopy (CCE) has proven efficacy in a variety of gastrointestinal diseases. Few studies have assessed patient-reported outcomes and preference between colonoscopy and CCE. Methods Patients ... -
Development of significant disease in a cohort of patients with non-specific enteritis on capsule endoscopy: clinical suspicion and a high base line Lewis score are predictive of Crohn's disease.
(2020)Background: As with isolated ileitis the findings of nonspecific small bowel enteritis (NSE) on capsule endoscopy (CE) poses a clinical challenge. There is lack of available evidence to help clinicians to predict significant ... -
Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett?s oesophagus?.
(2014)Contemporary clinical management of Barrett's oesophagus has highlighted the lack of accurate predictive markers of disease progression to oesophageal cancer. This study aims to examine alterations in mitochondrial energy ... -
Dye-based chromoendoscopy following polypectomy reduces incomplete polyp resection.
(2020)Background and study aims: The completeness of a polyp resection is an important determinant of quality in colonoscopy, and may reduce incidence of interval cancers. Incomplete resection rates (IRR) vary widely and range ... -
?Dysregulated bioenergetics: a key regulator of joint inflammation?.
(2016)Objectives: This study examines the relationship between synovial hypoxia and cellular bioenergetics with synovial inflammation. Methods: Primary rheumatoid arthritis synovial fibroblasts (RASF) were cultured with ... -
?Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity?.
(2016)In Barrett associated tumorigenesis, oxidative phosphorylation and glycolysis are reprogrammed early in the disease sequence and act mutually to promote disease progression. However, the link between energy metabolism and ... -
Gastrointestinal manifestations in a patient with common variable immunodeficiency syndrome.
(2019)A 57 yo male with a background history of common variable Immunodeficiency syndrome (CVID) on Immunoglobulin Infusion (Kiovig) 40mg three weekly was referred for investigation of diarrhoea and follow up from previous history ... -
Healthy Eating, Food Safety and Food Legislation: A Guide Supporting the Healthy Ireland Food Pyramid
(2019)This guide provides extended information to support the Healthy Ireland Food Pyramid 2016, which is based on international best practice and tailored to meet the specific needs of Ireland’s population. These healthy ... -
Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples.
(2020)Background: An increasing number of anti‐cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absence ... -
Ifosfamide-induced encephalopathy: the EEG with frontal intermittent delta activity, and rapid resolution with methylene blue: A case report.
(2020)Background: Encephalopathy is an established side effect of the chemotherapeutic agent, ifosfamide, occurring in 10-30% of cases. The EEG commonly shows non-specific features of encephalopathy, and rarely shows frontal ... -
IL-1 family members in health and disease
(2019)In 1985, two distinct cDNAs encoding proteins sharing human Interleukin-1 (IL-1) activity were described, thus defining the first two members of the IL-1 family – IL-1α and IL-1β. These potent pro-inflammatory cytokines ... -
Key research questions for implementation of artificial intelligence in capsule endoscopy.
(2022)Background: Artificial intelligence (AI) is rapidly infiltrating multiple areas in medicine, with gastrointestinal endoscopy paving the way in both research and clinical applications. Multiple challenges associated with ... -
Kidney Function Estimated From Cystatin C, But Not Creatinine, Is Related to Objective Tests of Physical Performance in Community-Dwelling Older Adults
(2017)Background: The burden of chronic kidney disease is highest among older adults but the significance of a diminished level of kidney function in this heterogeneous population is poorly understood. We sought to examine ... -
L-Plastin Expression in HCT 116 Colorectal Cells increases migration and ROS in an NADPH Oxidase-dependent manner
(2022)Objective: L-plastin is an action-bundling protein normally expressed in cells of haemopoietic origin but is also associated with malignant transformation. Aberrant expression of L-plastin expression correlates with tumour ...