Browsing Clinical Medicine (Scholarly Publications) by Author "O'BYRNE, KEN"
Now showing items 1-20 of 26
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2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up.
O'BYRNE, KEN (2014)To complement the existing treatment guidelines for all tumour types, ESMO organises consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO Consensus Conference on Lung Cancer was held on ... -
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising.
O'BYRNE, KEN (2014)The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell’s genetic material and can lead to genomic ... -
Enrichment of circulating head and neck tumour cells using spiral microfluidic technology
O'BYRNE, KEN (2017)Whilst locoregional control of head and neck cancers (HNCs) has improved over the last four decades, long-term survival has remained largely unchanged. A possible reason for this is that the rate of distant metastasis has ... -
Epigenetic Regulation of Glucose Transporters in Non-Small Cell Lung Cancer
O'BYRNE, KEN; BAIRD, ANNE-MARIE; GRAY, STEVEN (MDPI, 2011)Due to their inherently hypoxic environment, cancer cells often resort to glycolysis, or the anaerobic breakdown of glucose to form ATP to provide for their energy needs, known as the Warburg effect. At the same time, ... -
Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer
O'BYRNE, KEN; BAIRD, ANNE-MARIE; GRAY, STEVEN (PLoS, 2011)Background: Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR+) chemokine family are powerful promoters of the angiogenic response. Methods: The expression of the CXC ... -
The establishment of an ISO compliant cancer biobank for Jordan and its neighboring countries through knowledge transfer and training.
BARR, MARTIN; GATELY, KATHY; O'BYRNE, KEN (2014)Research studies aimed at advancing cancer prevention, diagnosis, and treatment depend on a number of key resources, including a ready supply of high-quality annotated biospecimens from diverse ethnic populations that can ... -
Functions and therapeutic roles of exosomes in cancer.
O'BYRNE, KEN (2014)The role of exosomes in cancer development has become the focus of much research, due to the many emerging roles possessed by exosomes. These micro-vesicles that are ubiquitously released in to the extracellular milieu, ... -
Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature
O'BYRNE, KEN (2013)NTRODUCTION: Inherent and acquired cisplatin resistance reduces the effectiveness of this agent in the management of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms underlying this process may ... -
Genome stability pathways in head and neck cancers.
O'BYRNE, KEN (2013)Genomic instability underlies the transformation of host cells toward malignancy, promotes development of invasion and metastasis and shapes the response of established cancer to treatment. In this review, we discuss recent ... -
HSSB1 (NABP2/OBFC2B) is regulated by oxidative stress
O'BYRNE, KEN (2016)The maintenance of genome stability is an essential cellular process to prevent the development of diseases including cancer. hSSB1 (NABP2/ OBFC2A) is a critical component of the DNA damage response where it participates ... -
hSSB1 associates with and promotes stability of the BLM helicase
O'BYRNE, KEN (2017) -
IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer.
DOHERTY, DEREK; BAIRD, ANNE-MARIE; GRAY, STEVEN; O'BYRNE, KEN (2013)The Interleukin-23 (IL-23)/IL-23R signaling axis is an important inflammatory pathway, involved in the stimulation and regulation of the T helper (Th) 17 lymphocytes, resulting in the production of IL-17. Aside from ... -
Long non coding RNAs (lncRNAs) are dysregulated in Malignant Pleural Mesothelioma (MPM).
GRAY, STEVEN; O'BYRNE, KEN (2013)Malignant Pleural Mesothelioma (MPM) is an aggressive cancer that is often diagnosed at an advanced stage and is characterized by a long latency period (20–40 years between initial exposure and diagnosis) and prior exposure ... -
Nucleophosmin: From structure and function to disease development
O'BYRNE, KEN (2016)Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement ... -
Prognostic and therapeutic relevance of FLIP and procaspase-8 overexpression in non-small cell lung cancer
O'BYRNE, KEN (2013)Non-small cell lung carcinoma remains by far the leading cause of cancer-related deaths worldwide. Overexpression of FLIP, which blocks the extrinsic apoptotic pathway by inhibiting caspase-8 activation, has been identified ... -
RanGTPase: A Candidate for Myc-Mediated Cancer Progression
O'BYRNE, KEN (2013)BACKGROUND: Ras-related nuclear protein (Ran) is required for cancer cell survival in vitro and human cancer progression, but the molecular mechanisms are largely unknown. METHODS: We investigated the effect of the ...