Browsing Clinical Medicine (Scholarly Publications) by Author "KELLEHER, DERMOT P"
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A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma
KELLEHER, DERMOT P; MCMANUS, ROSS (Nature, 2001)The incidence of oesophageal adenocarcinoma is rising; to date, no susceptibility genes have been identified. p73, a novel p53 homologue, maps to chromosome 1p36, a region commonly deleted in oesophageal cancers. p73 shares ... -
Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction
KELLEHER, DERMOT P; MILLS, KINGSTON; ROCHE, HELEN (The American Association of Immunologists, 2005)Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses and have therapeutic effects in inflammatory disorders. However, the influence of PUFA on dendritic cells (DC), key cells of the innate immune ... -
Genetic Polymorphisms and the Risk of Infection Following Esophagectomy
KELLEHER, DERMOT P; MCMANUS, ROSS (Lippincott Williams & Wilkins, 2007)OBJECTIVE: To examine the association of single nucleotide polymorphisms (SNPs) in inflammation-related genes in the development of infections following esophagectomy. SUMMARY BACKGROUND DATA: Genetic polymorphisms for ...