Browsing Clinical Medicine (Scholarly Publications) by Author "Johnston, Daniel"
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MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.
Fallon, Padraic; Corr, Sinead; Johnston, Daniel (2014)Toll-like receptors (TLRs) play a central role in the recognition and response to microbial pathogens and in the maintenance and function of the epithelial barrier integrity in the gut. The protein MyD88 adaptor-like ... -
Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.
Palsson Mcdermott, Eva; Keane, Joseph; O'Neill, Luke; Sheedy, Frederick; Johnston, Daniel; Gleeson, Laura (2015)TLR4-activated macrophages switch their metabolism from oxidative phosphorylation to glycolysis to rapidly provide for the high energy and biosynthetic demands of infection or injury response. Palsson-McDermott identify ...