Browsing Clinical Medicine (Scholarly Publications) by Author "Gately, Kathy"
Now showing items 1-5 of 5
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Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
O'Byrne, Ken; Gately, Kathy; Baird, Anne-Marie (2016)Apoptosis is a highly regulated cellular process that functions to remove undesired cells from multicellular organisms. This pathway is often disrupted in cancer, providing tumours with a mechanism to avoid cell death and ... -
Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines.
Barr, Martin; O'Byrne, Ken; Finn, Stephen; Gately, Kathy; Maher, Stephen (2018) -
Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples.
Gately, Kathy; Rafee, Shereen; Kelleher, Fergal (2020)Background: An increasing number of anti‐cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absence ... -
In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC
O'Byrne, Ken; Finn, Stephen; Gately, Kathy (2016)Clinical PI3K inhibition has been somewhat disappointing, due to both inadequate patient stratification and compensatory cell signalling through bypass mechanisms. As such, investigation of PI3K-MEK co-targeted inhibition ... -
Targeting nuclear factor-kappa B to overcome resistance to chemotherapy.
O'Byrne, Ken; Gately, Kathy; Barr, Martin; Baird, Anne-Marie (2013)Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug ...