Browsing Clinical Medicine (Scholarly Publications) by Author "GILMER, JOHN"
Now showing items 1-3 of 3
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New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
LONG, AIDEEN; GILMER, JOHN; EHRHARDT, CARSTEN; WANG, JUN; SALOMON, JOHANNA JESSICA; MAJER, FERENC; KEAVENY, RAYMOND; SHARMA, RUCHIKA (2012)Deoxycholic acid (DCA), a secondary bile acid (BA), and ursodeoxycholic acid (UDCA), a tertiary BA, cause opposing effects in vivo and in cell suspensions. Fluorescent analogues of DCA and UDCA could help investigate ... -
Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism
GILMER, JOHN; LONG, AIDEEN; Sharma, Ruchika; Quilty, Francis; Byrne, Anne-Marie (2017)Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids ... -
Ursodeoxycholic acid attenuates colonic epithelial secretory function.
GILMER, JOHN; FALLON, PADRAIC (2013)Dihydroxy bile acids, such as chenodeoxycholic acid (CDCA), are well known to promote colonic fluid and electrolyte secretion, thereby causing diarrhoea associated with bile acid malabsorption. However, CDCA is rapidly ...