Browsing Clinical Medicine (Scholarly Publications) by Author "Finn, Stephen"
Now showing items 1-3 of 3
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Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines.
Barr, Martin; O'Byrne, Ken; Finn, Stephen; Gately, Kathy; Maher, Stephen (2018) -
Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids.
Gray, Steven; Oner-Bozkurt, Ezgi; Finn, Stephen; Baird, Anne-Marie (2021)Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ... -
In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC
O'Byrne, Ken; Finn, Stephen; Gately, Kathy (2016)Clinical PI3K inhibition has been somewhat disappointing, due to both inadequate patient stratification and compensatory cell signalling through bypass mechanisms. As such, investigation of PI3K-MEK co-targeted inhibition ...