Browsing Clinical Medicine (Scholarly Publications) by Author "Bede, Peter"
Now showing items 1-6 of 6
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Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study.
Bede, Peter; Rooney, James (2021)Background Amyotrophic lateral sclerosis (ALS) is often associated with cognitive and/or behavioural impairment. Cognitive reserve (CR) may play a protective role in offsetting cognitive impairment. This study examined the ... -
Dysfunction of attention switching networks in amyotrophic lateral sclerosis.
Bede, Peter; Hardiman, Orla; Lalor, Edmund (2019)Objective: To localise and characterise changes in cognitive networks in Amyotrophic Lateral Sclerosis (ALS) using source analysis of mismatch negativity (MMN) waveforms. Rationale: The MMN waveform has an increased average ... -
Mismatch Negativity as an Indicator of Cognitive Sub-Domain Dysfunction in Amyotrophic Lateral Sclerosis
Bede, Peter; Mc Laughlin, Russell; Nasseroleslami, Bahman; Lalor, Edmund; Hardiman, Orla (2017)Objective: To evaluate the utility of mismatch negativity (MMN), a neurophysiologic marker of non-motor cognitive processing, in amyotrophic lateral sclerosis (ALS). Methods: 89 patients, stratified into 4 different ... -
Neurophysiological markers of network dysfunction in neurodegenerative diseases
Bede, Peter; Hardiman, Orla; Pender, Niall (Elsevier, 2019)There is strong clinical, imaging and pathological evidence that neurodegeneration is associated with altered brain connectivity. While functional imaging (fMRI) can detect resting and activated states of metabolic activity, ... -
Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease
Bede, Peter; Hardiman, Orla (2019)Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive, mechanisms of progression are ... -
Virtual brain biopsies in amyotrophic lateral sclerosis: diagnostic classification based on in vivo pathological patterns
Bede, Peter; Hardiman, Orla; Finegan, Eoin; Omer, Taha; Iyer, Parameswaran M. (2017)Background: Diagnostic uncertainty in ALS has serious management implications and delays recruitment into clinical trials. Emerging evidence of presymptomatic disease-burden provides the rationale to develop diagnostic ...