Browsing Clinical Medicine (Scholarly Publications) by Author "Basdeo, Sharee"
Now showing items 1-3 of 3
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Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis
Phelan, James; Keane, Joseph; Basdeo, Sharee; O'Sullivan, Mary; O'Neill, Luke (2020)Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis ... -
Inhibiting Histone Deacetylases in Human Macrophages Promotes Glycolysis, IL-1β, and T Helper Cell Responses to Mycobacterium tuberculosis
Phelan, James; Keane, Joseph; Basdeo, Sharee (2020)Tuberculosis (TB) is the leading infectious killer in the world. Mycobacterium tuberculosis (Mtb), the bacteria that causes the disease, is phagocytosed by alveolar macrophages (AM) and infiltrating monocyte-derived ... -
Modulating Iron for Metabolic Support of TB Host Defense
Phelan, James; Keane, Joseph; Basdeo, Sharee (2018)Tuberculosis (TB) is the world's biggest infectious disease killer. The increasing prevalence of multidrug-resistant and extensively drug-resistant TB demonstrates that current treatments are inadequate and there is an ...