Clinical Medicine (Theses and Dissertations): Recent submissions
Now showing items 1-5 of 310
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Characterising Macrophage Immunometabolism in Mycobacterium tuberculosis and HIV Co-Infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Tuberculosis (TB) and HIV are leading infection-related causes of global mortality and result in an enormous amount of suffering and economic loss. Available TB treatment strategies are inadequate, and vaccination ... -
Investigation of the role of immunomodulators oftoll-like receptor 3 (TLR3) function and associated genetic variants in the pathogenesis and progression of idiopathic pulmonary fibrosis (IPF)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)IPF is a fatal interstitial lung disease of unknown aetiology, with a lack of valid biomarkers and satisfactory therapeutic solutions available. Studies have shown an association between inflammation, viral and bacterial ... -
Genotypic and phenotypic insights into an Irish axial spondyloarthritis cohort
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Axial spondyloarthritis (AxSpA) encompasses a group of closely related chronic inflammatory conditions which primarily affect the lumbar spine. The prototypic presentation of the disease is ankylosing spondylitis, which ... -
Investigating a role for SARM1 in retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), represent a leading cause of incurable blindness worldwide. RP is a genetically inherited retinal degeneration ... -
Profiling Serum and Tissue Biomarkers of Vedolizumab Therapy Response in Inflammatory Bowel Disease.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Vedolizumab (VDZ) is a novel biologic agent proven effective for Inflammatory bowel disease (IBD), however, a significant proportion of patients do not respond to VZD treatment Aims: This thesis evaluates ...