Browsing Clinical Medicine (Theses and Dissertations) by Author "Dorris, Emma R."
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Molecular mechanisms of resistance to therapeutic MEK inhibition in BRAF [V600E] cancer
Dorris, Emma R. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)Aberrant activation of the mitogen activated protein kinase (MAPK) pathway is common in solid tumours. This hierarchical pathway consists of a three-tiered kinase casade of BRAF, MAPK kinase (MEK1/2) and the extracellular ...