Browsing Microbiology (Theses and Dissertations) by Date of Publication
Now showing items 21-40 of 84
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Characterization of peptide mimics to antigens chaperoned by Hsp70 in MDA-MB-231 breast tumour cells
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)Tumour-derived heat shock protein (Hsp) preparations have been shown to elicit anti-tumour immune responses in both mice and man. Analysis of Hsp preparations from tumour cells revealed that the immuno-protective property ... -
Analysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids
(Trinity College (Dublin, Ireland). Department of Microbiology, 2005)Long-term potentiation (LTP) is considered to be a possible neurophysiological model for learning and memory and consistent with this, is the observation that LTP is sensitive to stress, injury and insult. This thesis ... -
Molecular genetic typing of Staphylococcus aureus from cows, goats, sheep, rabbits and chickens
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Staphylococcus aureus is an important pathogen of man causing a range of infections from boils, carbuncles and abscesses to more serious and life-threatening infections like endocarditis and osteomyelitis. S. aureus is ... -
Studies on clumping Factor A of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Clumping factor A is a fibrinogen-binding protein of S. aureus. It is a cell wall associated protein consisting of an N-terminal ligand-binding region A, an unusual SD dipeptide repeat region, which acts as a stalk to ... -
Structure-function analysis of the Fim-B and Fim-E site-specific recombinases of Escherichia coli K-12
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Phase variable expression of type 1 fimbriae in Escherichia coli arises from a site-specific recombination event that inverts a 314 bp segment of chromosomal DNA (fimS) carrying the promoter for transcription of the gene ... -
Adhesion and invasion by Escherichia coli K1
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Escherichia coli is one of the principal causes of septicaemia and meningitis in neonates. Sepsis occurs in approximately one in every thousand live births, with up to 10% progressing to develop meningitis. A disproportionate ... -
Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-beta on the progression of experimental autoimmune encephalomyelitis
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Multiple sclerosis (MS) is an autoimmune demyelinating disease of the CNS, characterized by the presence of sclerotic lesions throughout the brain. MS is thought to be a CD4+ T helper 1 disease caused by the infiltration ... -
Characterisation of Sfh, a novel H-NS-like protein
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Members of the H-NS protein family are widespread among Gram-negative bacteria and are known to influence gene expression at a global level. Shigella flexneri serotype 2a strain 2457T expresses three members of the H-NS ... -
Platelet activation by Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)Staphylococcus aureus is the leading cause of infective endocarditis (IE). Platelet activation promoted by S. aureus resulting in aggregation and thrombus formation is thought to be an important step in the pathogenesis ... -
Sequence analysis of alphavirus pathogenesis
(Trinity College (Dublin, Ireland). Department of Microbiology, 2006)This investigation involved the sequencing and characterisation of Chikungunya virus (CHIKV), a positive-stranded RNA virus with a genome spanning 11.8 kb. The prototype strain of CHIKV, termed Ross was used. This is the ... -
Molecular characterisation of the Salmonella-specific protein PagN
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Salmonella infect a broad spectrum of animals resulting in host responses ranging from severe disease to asymptomatic carriage. Infection of a host gives rise to symptoms such as fever or self-limiting gastroenteritis. ... -
Biogenesis of histone mRNAs in the yeast Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The typical eukaryotic human diploid cell contains 3.2x10 9 base pairs of deoxyribonucleic acid (DNA) which, if presented in an extended form, would measure 1.2m in length. The large amount of DNA is tightly wrapped and ... -
The genome of Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The base distribution of the 14 nuclear chromsomes, of the plastid and the mitochondrion of the malarial parasite Plasmodium falciparum were studied. Isochores were discovered in the nuclear chromosomes and found to be ... -
Construction and characterisation of a Semliki Forest virus vector based rubella prototype vaccine
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Alphavirus vaccines such as those based on the Semliki Forest virus (SFV) replicon have been widely studied as candidate vaccines. Following intramuscular injection, dispersal of the RNA occurs to the local lymph node only, ... -
Gene regulation and the leucine-responsive regulatory protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The leucine-responsive regulatory protein of Escherichia coli (E. coli) is a well characterised global regulator of transcription. Comparatively little is known about the Lrp regulon of Salmonella enterica serovar ... -
Molecular analysis of the interaction between protein A of Staphylococcus aureus and von Willebrand factor
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)Staphylococcus aureus continues to be a major cause of infection in normal as well as immunocompromised hosts, and the increasing prevalence of highly virulent community acquired methicillin-resistant strains is a public ... -
Molecular characterisation of Region A of FnBPA from Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2007)The surface-expressed fibronectin-binding proteins, FnBPA and FnBPB, of Staphylococcus aureus promote attachment to immobilised fibrinogen and elastin via the N-Terminal A region. The N2N3 subdomains of region A were found ... -
Characterisation of the Rns transcriptional regulator of enterotoxigenic Escherichia coli and regulationf of CS1 fimbrial expression
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrhoea amongst children in developing countries and travellers to such countries. Virulence in ETEC is dependent on both toxin production and adherence of the ... -
The cell biology of microtubule inhibition in Plasmodium falciparum
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Malaria is among the most prevalent human infections worldwide and both the lack of a viable vaccine and the spread of resistance to commonly used drugs have limited the options for control of the parasite, especially ... -
The Dps protein of Salmonella enterica serovar Typhimurium
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)As a nucleoid-associated protein, Dps has long been thought to influence gene expression at a global level. In this study the role of Dps in genetic regulation in Salmonella enterica serovar Typhimurium was investigated. ...