Browsing Histopathology & Morbid Anatomy (Theses and Dissertations) by Subject "Histopathology, Ph.D."
Now showing items 1-12 of 12
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C-ABL in human cancer: an investigation of its role in apoptosis inhibition, differentiation and angiogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)Research over the past number of decades has significantly advanced our understanding of the cell signalling effects that mediate a diverse array of cellular activities including cell proliferation, homeostasis and ... -
Cancer cell-platelet interactions in ovarian cancer metastasis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Ovarian cancer is the leading cause of death from gynaecological malignancy worldwide with an estimated global incidence of 225,900 and mortality of 140,200 per year. In Ireland ovarian cancer is the second most common ... -
Development of extraction and analysis of protocols for RNA in formalin-fixed paraffin-embedded (FFPE) materials using TaqMan® real-time PCR
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Archival Formalin-Fixed, Paraffin-Embedded (FFPE) tissue samples represent an invaluable source of human tissue for gene expression analysis. They are the most abundant and readily available materials and generally well ... -
HPV mRNA and p16[ink4a] / Ki-67 detection for improved diagnosis and management of cervical neoplasia in smokers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Persistent infection with high risk human papillomavirus (HR HPV) is the main etiological agent in the development of cervical cancer. The use of HPV DNA testing in cervical screening programs is becoming increasingly ... -
Investigation of oral and oropharyngeal squamous cell carcinoma in young adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2006)While oral and pharyngeal squamous cell carcinoma is classically a disease of older male smokers, this tumour type can occur in young patients with minimal or no exposure to the traditional risk factors. The prognosis ... -
Molecular algorithms in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2005)Papillary thyroid carcinoma is the most comm on thyroid malignancy, with an incidence of <100 cases per year in Ireland and 16,000 cases per year in the U.S. Incidence is increasing with a global estimate of half a million ... -
Molecular markers in cervical cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2004)Despite the introduction of the Papanicolaou (Pap) test carcinoma of the cervix remains one of the most common malignancies amongst women worldwide. It is hoped that the use of HPV testing and molecular biomarkers in ... -
Molecular signatures of prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2008)Prostate cancer is the second most common cancer in Irish men and the second most common cause of cancer-related deaths. In the United States, there are approximately 234,000 new cases diagnosed every year and 27,350 deaths. ... -
Non-coding RNA expression in cancer stem cell progenies derived from tumours +/-BRAF V600E mutation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Cancer has placed a huge burden on the global health system and rising rates in particular cancer types such as lung cancer and melanoma due to smoking and increased UV ray exposure respectively has highlighted the need ... -
Post-transcriptional Dysregulation by microRNAs is implicated in the Pathogenesis of Gastrointestinal Stromal Tumour [GIST]
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)In a cohort of 73 GISTs including adult mutant, adult wild-type and paediatric cases miRNA expression was examined using TaqMan® Low Density Arrays (TLDAs), allowing the profiling of 667 miRNAs in a set of two (pool A and ... -
Prognostic markers in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2000)Prognosis in thyroid carcinoma is usually assessed on the basis of criteria, which include patient age and histological type, grade and stage of tumour. It is well recognised, however, that while occasional tumours with ... -
The expression and function of miRNAs in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer deaths each year. Carcinomas of the thyroid comprise a heterogeneous group of neoplasms with distinctive clinical and ...
