Browsing Histopathology & Morbid Anatomy (Theses and Dissertations) by Title
Now showing items 19-38 of 44
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MicroRNA profiling in prostate cancer and prostate derived holoclone cell model
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Prostate cancer is a heterogeneous disease and is the most commonly diagnosed malignant tumour and the second most common cause of cancer deaths in western males. Prostate cancer is the most commonly diagnosed cancer in ... -
Molecular algorithms in ovarian serous neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Epithelial ovarian cancer is one of the most common cancers in women and the leading cause of death from gynaecological malignancy in the western world. Approximately 205,000 cases of ovarian cancer are diagnosed worldwide ... -
Molecular algorithms in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2005)Papillary thyroid carcinoma is the most comm on thyroid malignancy, with an incidence of <100 cases per year in Ireland and 16,000 cases per year in the U.S. Incidence is increasing with a global estimate of half a million ... -
Molecular analysis of Human Herpes Virus 8 and associated lesions
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)This thesis looks at the bio-pathways of HHV8 through the transformation of endothelial cell lines. This was performed in two separate but mutually contributing experiments. First, endothelial cell lines were infected using ... -
Molecular characterisation of a new variant of inflammatory bowel disease in children with autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2004)A new variant of inflammatory bowel disease, provisionally termed "autistic enterocolitis" has been described in a cohort of children with autistic spectrum disorders. The intestinal pathology includes ileo-colonic ... -
Molecular features of aggressive prostate carcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)Prostate cancer is the most common form of malignancy in the male urinary tract and accounts for more than 20% of all newly diagnosed male cancer cases. The vast majority of prostate tumours are clinically insignificant, ... -
Molecular gene and regulatory profiles in thyroid cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Thyroid carcinoma is the most common endocrine malignancy, with an incidence of approximately eighty cases per year in Ireland and thirty seven thousand cases per year in the United States. While thyroid cancer may be ... -
Molecular markers in cervical cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2004)Despite the introduction of the Papanicolaou (Pap) test carcinoma of the cervix remains one of the most common malignancies amongst women worldwide. It is hoped that the use of HPV testing and molecular biomarkers in ... -
Molecular Mechanisms of Advanced Prostate Cancer
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2018)Globally, prostate cancer is the fourth most common cancer type. Five year survival rates for primary localised disease are high, however these figures decrease significantly with the onset of metastasis. Obesity and ... -
Molecular signatures in papillary thyroid carcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2007)Papillary thyroid carcinomas (PTC) are the most frequently occurring type of thyroid malignancy (85%-90%). PTC affects females more frequently than males, with a ratio of 3:1 and can be present in any age group, the mean ... -
Molecular signatures of prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2008)Prostate cancer is the second most common cancer in Irish men and the second most common cause of cancer-related deaths. In the United States, there are approximately 234,000 new cases diagnosed every year and 27,350 deaths. ... -
Molecular targeting of HPV oncogenes and oncogenic protein
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)Worldwide cervical cancer is the second most common cause of cancer related death in women. Over the last three decades high-risk HPV has been conclusively established as the major etiological factor in cervical cancer and ... -
MyD88 : a key regulator of chemoresistance, differentiation and hypoxia resistance in cancer stem cells?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer, the leading cause of gynaecologic cancer deaths in the western world is characterised by high rates of chemoresistant recurrence. While in primary cases, differentiation status of the tumour is considered ... -
Non-coding RNA expression in cancer stem cell progenies derived from tumours +/-BRAF V600E mutation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Cancer has placed a huge burden on the global health system and rising rates in particular cancer types such as lung cancer and melanoma due to smoking and increased UV ray exposure respectively has highlighted the need ... -
Platelet-cancer Cell Interactions induce PAI-1 Expression in an Ovarian Cancer Cell Line Model: Implications for the Metastasis of Epithelial Ovarian Cancer
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2021)This thesis encompasses an investigation into the function of plasminogen activator inhibitor 1 (PAI-1) - a serine protease inhibitor integral to coagulation and fibrinolysis that has been identified as both a key factor ... -
Platinum and taxane chemoresistance mechanisms in ovarian cancer cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)Ovarian cancer is the leading cause of death from a gynaecological malignancy, typically presenting at late stage due to difficult diagnosis and lack of suitable screening tools. The standard treatment of combination ... -
Post-transcriptional Dysregulation by microRNAs is implicated in the Pathogenesis of Gastrointestinal Stromal Tumour [GIST]
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)In a cohort of 73 GISTs including adult mutant, adult wild-type and paediatric cases miRNA expression was examined using TaqMan® Low Density Arrays (TLDAs), allowing the profiling of 667 miRNAs in a set of two (pool A and ... -
Prognostic markers in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2000)Prognosis in thyroid carcinoma is usually assessed on the basis of criteria, which include patient age and histological type, grade and stage of tumour. It is well recognised, however, that while occasional tumours with ... -
Regulation of cancer stem cell differentiation by genes and microRNAs
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Since the discovery of a stem cell phenotype in cancer, specific tumour cells with this phenotype, often called cancer stem cells (CSCs), are now widely accepted as the progenitors of oncogenesis, proliferation, treatment ... -
Targeting the prostate cancer metabolome with novel trojan horse compounds.
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2023)Prostate cancer (PCa) is the second most common cancer diagnosed in males worldwide, and the incidence of this disease is predicted to double globally by 2030. In Ireland, PCa accounts for nearly 16% of all invasive cancers ...
