Browsing Physiology (Scholarly Publications) by Title
Now showing items 5-24 of 136
-
Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.
(2011)The blockade of adenosine A2A receptors (A2AR) affords a robust neuroprotection in different noxious brain conditions. However, the mechanisms underlying this general neuroprotection are unknown. One possible mechanism ... -
The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation
(2011)The family of reticulons include 3 isoforms of the Nogo protein, Nogo A, Nogo B and Nogo C. Nogo A is expressed on neuronal tissue and its primary effect is widely acknowledged to be inhibition of neurite outgrowth. Although ... -
Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice
(2014)Aging adversely affects inflammatory processes in the brain, which has important implications in the context of disease progression. It has been proposed that microglia become dysfunctional with age and may lose their ... -
Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL
(2012)Altered synaptic morphology, progressive loss of synapses and glial (astrocyte and microglial) cell activation are considered as characteristic hallmarks of ageing. Recent evidence suggests that there is a concomitant ... -
The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability.
(2012)In view of the increase in the aging population and the unavoidable parallel increase in the incidence of age-related neurodegenerative diseases, a key challenge in neuroscience is the identification of clinical signatures ... -
The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon.
(2013)A non-selective antihistamine, dimebon, has recently emerged as a potential treatment for Alzheimer's disease and Huntington's disease. Dimebon exerts several effects in addition to its anti-histaminergic effect, and of ... -
Age-related neuroinflammatory changes negatively impact on neuronal function.
(2010)Neuroinflammatory changes, characterized by an increase in microglial activation and often accompanied by upregulation of inflammatory cytokines like interleukin-1? (IL-1?), are common to many, if not all, neurodegenerative ... -
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.
(2008)The current development of immunotherapy for Alzheimer's disease is based on the assumption that human-derived amyloid beta protein (Abeta) can be targeted in a similar manner to animal cell-derived or synthetic Abeta. ... -
Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice.
(2007)The cleavage-product of amyloid precursor protein (APP) constitutes the core component of plaques found in the brains of Alzheimer's disease (AD) patients. APP is ubiquitously expressed and its precise physiological functions ... -
Analysing the operative experience of basic surgical trainees in Ireland using a web-based logbook
(BioMed Central, 2011)Background: There is concern about the adequacy of operative exposure in surgical training programmes, in the context of changing work practices. We aimed to quantify the operative exposure of all trainees on the National ... -
Androgen receptor signaling in prostate cancer development and progression
(Carcinogenesis Press, 2011)The androgen receptor (AR) signaling axis plays a critical role in the development, function and homeostasis of the prostate. The classical action of AR is to regulate gene transcriptional processes via AR nuclear ... -
The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK
(2001)Several effects of the proinflammatory cytokine, interleukin-1? (IL-1?), have been described in the central nervous system, and one area of the brain where marked changes have been reported is the hippocampus. Among these ... -
Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid
(2018)Background: Microglia are multifunctional cells that are primarily neuroprotective and a deficit in their functional integrity is likely to be a contributory factor in the deteriorating neuronal function that occurs with ... -
Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain
(2011)Abstract: Background: Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial ... -
BDNF-stimulated intracellular signalling mechanisms underlie exercise-induced improvement in spatial memory in the male Wistar rat.
(2014)Exercise-induced improvements in learning are associated with neurotrophic and neurogenic changes in the dentate gyrus, but the intracellular signalling mechanisms that may mediate these improvements remain unknown. In the ... -
Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide
(2004)The mechanisms underlying the inhibition of long-term potentiation (LTP) induction by amyloid -peptide (A ) were investigated in the medial perforant path of the rat and mouse dentate gyrus in vitro . Evidence ... -
Bimodal magnetic-fluorescent nanostructures for biomedical applications
(2009)Magnetite-based polyelectrolyte-coated nanostructures were fabricated and the potential for biomedical application assessed in mixed glial cell cultures with nanostructure cellular internalization, cytotoxicty and contribution ... -
Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli.
(2015)Macrophages are key cells in tissue defense in the periphery and, under certain circumstances, infiltrate the central nervous system, where they may play a similar role in the brain, perhaps supporting the function of ... -
Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli
(2015)Background Lipopolysaccharide (LPS) and interferon-γ (IFNγ) increase expression of tumour necrosis factor-α (TNFα) that characterizes the M1 activation state of macrophages. Whereas it is accepted that the immune system ...