Browsing Physiology (Theses and Dissertations) by Sponsor "Trinity College Dublin (TCD)"
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Central and peripheral characterisation of TLR7/8 and endocannabinoid signalling in multiple sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2022)Toll-like receptors (TLRs) are a class of pattern-recognition receptors (PRRs) involved in initiating an immune response to infection or endogenous damage. These receptors are expressed on cells of both the innate and ... -
The effects of clozapine and haloperidol on astrocyte function and morphology
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)Schizophrenia is a chronic debilitating psychiatric disorder affecting approximately 1% of the population worldwide. The disorder is characterised by positive symptoms, negative symptoms, and clinical deficits in cognition. ... -
The interactions of apolipoprotein E and inflammation in human iPSC-derived astrocytes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer’s disease (AD) is a devastating neurodegenerative disease characterised histologically by the presence of extracellular plaques and intracellular neurofibrillary tangles, and clinically by memory ... -
The role of GPR55 in neuronal and immune cell signalling and function
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)The orphan G-protein coupled receptor, GPR55, is widely expressed throughout the body and is responsive to cannabinoids. However, its endogenous ligand is believed to be L-a-lysophosphatidylinositol (LPI). GPR55 is expressed ...