Browsing Physiology (Theses and Dissertations) by Sponsor "Health Research Board (HRB)"
Now showing items 1-4 of 4
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Effects of high -intensity interval vs moderate-intensity continous training on the time course adapations in cardiovascular fitness and oxygen uptake kinetics in type 2 diabetes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)Individuals with type 2 diabetes mellitus (T2DM) present with significant impairments in the dynamic and peak responses of pulmonary oxygen uptake (V̇O2) during exercise. Both low-volume high-intensity interval training ... -
Investigating the Effects of FTY720 on Spatial Memory and Neuroinflammation in a Rodent Model of Alzheimer's Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder characterized by memory loss and cognitive decline, with loss of global functioning over time eventually leading to death. At the molecular ... -
Pulmonary oxygen uptake and muscle deoxygenation responses during ramp incremental exercise and moderate- and heavy-intensity exercise subsequent to priming exercise in type 2 diabetes.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2017)Middle-aged and young individuals with uncomplicated type 2 diabetes mellitus (T2DM) consistently demonstrate impairments in submaximal and maximal exercise performance, which are independent of obesity, and present in the ... -
Targeting the Sphingosine 1-Phosphate Axis as a Therapeutic Strategy in Krabbe's Disease: A Pre-Clinical Study.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Krabbe's disease (KD, globoid cell leukodystrophy) is a rare infantile neurodegenerative disorder, caused by the defective gene galc encoding the lysosomal hydrolase galactosylceramidase (GALC). A subsequent decreased ...