Catalytic, asymmetric azidations at carbonyls: achiral and meso-anhydride desymmetrisation affords enantioenriched ?-lactams
Citation:
Smith S.N., Trujillo C., Connon S.J., Catalytic, asymmetric azidations at carbonyls: achiral and meso-anhydride desymmetrisation affords enantioenriched ?-lactams, Organic and Biomolecular Chemistry, 20, 32, 2022, 6384 - 6393, 6384-6393Abstract:
An unprecedented organocatalytic process involving the asymmetric addition of azide to meso-anhydrides has been developed, promoted by novel sulfamide-substituted Cinchona alkaloid-based catalysts. Readily available glutaric anhydrides can be smoothly converted to enantioenriched hemi-acyl azides and from there to either γ-amino acids or γ-lactams.
Author's Homepage:
http://people.tcd.ie/connonsDescription:
PUBLISHED10.1039/d2ob01040b
Author: Connon, Stephen
Type of material:
Journal ArticleCollections
Series/Report no:
Organic and Biomolecular Chemistry20
32
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Full text availableKeywords:
azide, γ-amino acids, γ-lactams, meso-anhydridesDOI:
http://dx.doi.org/10.1039/d2ob01040bISSN:
14770520Metadata
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