Attention Deficit Hyperactivity Disorder (ADHD) and 5-HT2C receptor: A slight increase in the transmission of Cys23 to ADHD cases
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1999Access:
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Nugent E., Hawi Z., Lowe N., Kirley A., Fitzgerald M. & Gill M. , Attention Deficit Hyperactivity Disorder (ADHD) and 5-HT2C receptor: A slight increase in the transmission of Cys23 to ADHD cases, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 105, 7, 1999, 637Download Item:
Attention Deficit Hyperactivity Disorder (ADHD) and 5-HT2C receptor - A slight increase in the transmission of Cys23 to ADHD cases.pdf (Published (author's copy) - Peer Reviewed) 100.5Kb
Abstract:
Recent evidence suggests that interaction with and balancebetween serotonergicand dopaminergic neurotransmissionis important in the mediation of hyperactive behaviour.Animal model studies have ®rmly implicated the genes of theserotonergic system in predisposing to ADHD. Serotoninexerts its effects via a heterogenous family of receptors ofwhich there are at least 14 distinct subtypes.The non-speci®c serotonin receptor agonist (m-chlorophenylpiperazine)is known to suppress locomotion in normalmice. However, when administered to mice bearing amutated 5-HTR2C gene, it induces hyperactivity in theseanimals (Lora et al., 2000). This effect was blocked by pretreatmentwith 5HT1B receptor antagonist, indicating thatthe behavioural consequences of the mCPP-induced 5HT1Breceptor stimulation are unmasked in animals devoid of5HT2C receptor function. A Cysteine to Serine substitutionat amino acid 23 of the 5HT2C has been identi®ed whichmay in ̄uence the receptor folding thereby hindering the formation of a normal hydrophobic pocket and subsequentlythe binding of bulky ligands. In a family based associationstudy design, we analysed the Cys-Ser polymorphism at the5HT2C receptor gene in 60 Irish ADHD trios using transmissiondisequilibrium test (TDT). We observed a slightincrease in the transmission of the Cysteine allele to theaffected ADHD cases (Chi-square ˆ1.8, P ˆ 0.26). Thismay suggest the involvement of 5HT2C gene in predisposingto ADHD.
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http://people.tcd.ie/mifitzgeType of material:
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American Journal of Medical Genetics Part B: Neuropsychiatric Genetics;105;
7;
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Neuroscience , 5-HT2C , ADD/ADHD , ADD/ADHD , ADHD , ADHD , ADHD Lifetime Impairment Survey , ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) , Adolescent Psychiatry , Attention Deficit Hyperactivity Disorder (ADHD) , CHILD PSYCHIATRY , COMMUNITY PSYCHIATRY , CONSULTATION LIAISON PSYCHIATRY , CONSULTATION-LIAISON PSYCHIATRY , Cys23 , DISORDER ADHD , GENERAL HOSPITAL PSYCHIATRY , LIAISON PSYCHIATRY , Neuropsychiatry , Neuropsychiatry , PSYCHIATRY , Psychiatry , Psychiatry , TRAINEES IN PSYCHIATRY , adult ADHD , child and adolescent Psychiatry , neurodevelopmental psychiatryDOI:
doi/10.1002/ajmg.1595/pdfLicences: