Browsing by Subject "Psychiatry"
Now showing items 1-20 of 103
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Acoustic and Temporal Analysis of Speech: A Potential Biomarker for Schizophrenia
(2010)Currently, there are no established objective biomarkers for the diagnosis or monitoring of schizophrenia. It has been previously reported that there are notable qualitative differences in the speech of schizophrenics. The ... -
Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging
(Elsevier, 2009)Healthy aging is associated with brain volume reductions that involve the frontal cortex, but also affect other brain regions. We sought to identify an age-related network pattern of MRI gray matter using a multivariate ... -
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
(American Society for Biochemistry and Molecular Biology, 2005)Rac and its downstream effectors p21-activated kinase (PAK) family kinases regulate actin dynamics within growth cones to control neurite outgrowth during development. The activity of Rac is stimulated by guanine ... -
Altered Brain Activation During a Verbal Working Memory Task in Subjects with Amnestic Mild Cognitive Impairment.
(2010)In subjects with Mild Cognitive Impairment (MCI) memory disorders indicate a high risk for conversion to Alzheimer?s disease (AD). The objective of this study was to delineate the differences in brain activation between ... -
Are auditory-evoked frequency and duration mismatch negativity (MMN) deficits endophenotypic for schizophrenia? High-density electrical mapping in clinically unaffected first-degree relatives, recent-onset and chronic schizophrenia
(Elsevier, 2008)Mismatch negativity (MMN) is a negative-going event-related potential (ERP) component that occurs in response to intermittent changes in constant auditory backgrounds. A consistent finding across a large number of studies ... -
Assessing neuronal networks: Understanding Alzheimer's disease
(2009)Findings derived from neuroimaging of the structural and functional organization of the human brain have led to the widely supported hypothesis that neuronal networks of temporally coordinated brain activity across different ... -
Association between dopamine transporter (DAT1)genotype, left sided inattention, and an enhanced response to methylphenidate in attention deficit hyperactivity disorder
(2005)A polymorphism of the dopamine transporter gene (DAT1, 10-repeat) is associated with attention-deficit hyperactivity disorder (ADHD) and has been linked to an enhanced response to methylphenidate (MPH). One aspect of the ... -
Attention Deficit Hyperactivity Disorder (ADHD) and 5-HT2C receptor: A slight increase in the transmission of Cys23 to ADHD cases
(1999)Recent evidence suggests that interaction with and balancebetween serotonergicand dopaminergic neurotransmissionis important in the mediation of hyperactive behaviour.Animal model studies have ®rmly implicated the genes ... -
Autistic Tendencies: The Consequences for Our Culture
(2006)Professor Michael Fitzgeraldtalks withJoe Griffinabout the powerful impact, both positive and negative, of autistic thinking in diverse walks of life. -
Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease
(2010)Subjects with mild cognitive impairment (MCI) have an increased risk to develop Alzheimer?s disease (AD). Voxel-based MRI studies have demonstrated that widely distributed cortical and subcortical brain areas show atrophic ... -
Bipolar affective puerperal psychosis- genome-wide significant evidence for linkage to chromosome 16.
(American Psychiatric Publishing, 2007)OBJECTIVE: Vulnerability to the triggering of bipolar episodes by childbirth aggregates in families and may define a genetically relevant subtype of bipolar disorder. The authors conducted a search by systematic whole ... -
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
(American Society for Biochemistry and Molecular Biology, 2004)The amyloid precursor protein (APP) is proteolytically processed to release a C-terminal domain that signals to the nucleus to regulate transcription of responsive genes. The APP C terminus binds to a number of phosphotyrosine ... -
Cigarette smoking and psychotic symptoms in bipolar affective disorder
(The Royal College of Psychiatrists, 2001)Background An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Aims To determine whether smoking is associated with psychosis in bipolar affective ... -
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
(Nature Publishing Group, 2008)To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 10-9) in ANK3 (ankyrin G). We also ... -
Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q
(Elsevier, 2005)Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is that combining the ... -
Common variant at 16p11.2 conferring risk of psychosis
(2012)Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18?206 ... -
A complex morphofunctional approach for zinc toxicity evaluation in rats
(2020)Anthropogenic activity causes the introduction of zinc compounds into the biological cycle in mining and processing sites and its accumulation in organs and tissues, causing systemic toxicity. A cumulative effect of zinc ... -
Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31
(American Psychiatric Association, 2005)OBJECTIVE: Autism is a neurodevelopmental disorder with childhood onset and a known major genetic component. A recent study identified a highly significant association between autism and a two-single-nucleotide-polymorphism ...