Targeting DNA : synthesis, biophysical and biochemical studies of new aminoalkyl derivatives of diphenyl guanidines and acridine
Citation:
Caitriona McKeever, 'Targeting DNA : synthesis, biophysical and biochemical studies of new aminoalkyl derivatives of diphenyl guanidines and acridine', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2012, pp 310Download Item:
McKeever TCD THESIS 9812 Targeting DNA.pdf (PDF) 135.8Mb
Abstract:
Research on the design and synthesis of DNA targeting molecules is widespread. There are a number of diseases which are treated using DNA-targeting agents. DNA ligands have been shown to exhibit anticancer, antiprotozoal, antitrypanosomal, antiviral and antibacterial activity. Many of these drugs display promising results and a number are in clinical use against a variety of protozoal infections (Trypanosomiasis and malaria) and cancers. There are a number of minor groove binding/intercalator/alkylating or dual binding agents that display toxic side effects due to a lack of sequence specificity. Further, optimisation of DNA targeting agents is crucial so as new and improved agents can be discovered.
Author: McKeever, Caitriona
Advisor:
Rozas, IsobelQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
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Chemistry, Ph.D., Ph.D. Trinity College Dublin.Licences: