An investigation into the role of substrate stiffness and oxygen availability in the regulation of stem cell differentiation during tissue regeneration
Citation:
Darren Paul Burke, 'An investigation into the role of substrate stiffness and oxygen availability in the regulation of stem cell differentiation during tissue regeneration', [thesis], Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013, pp 249Download Item:
Burke TCD THESIS 10225 An investigation.pdf (PDF) 102.4Mb
Abstract:
Mesenchymal stem cells (MSCs) are multipotent cells which can differentiate down multiple
lineages and potentially generate tissues such as cartilage, bone or adipose tissue. It is becoming
increasingly clear that mechanical cues also play a key role in determining the fate of such cells.
Extrinsic mechanical stimuli such as tissue deformation, fluid flow and hydrostatic pressure
have often been implicated as regulators of tissue differentiation in vivo. It has been possible to
test different hypotheses for mechano-regulated MSC differentiation by attempting to simulate
regenerative events such as bone fracture repair, where repeatable spatial and temporal patterns
of tissue differentiation occur.
Author: Burke, Darren Paul
Advisor:
Kelly, Daniel J.Qualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing EngineeringNote:
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