Browsing by Subject "Bioengineering, Ph.D."
Now showing items 1-15 of 15
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An investigation into the role of substrate stiffness and oxygen availability in the regulation of stem cell differentiation during tissue regeneration
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)Mesenchymal stem cells (MSCs) are multipotent cells which can differentiate down multiple lineages and potentially generate tissues such as cartilage, bone or adipose tissue. It is becoming increasingly clear that mechanical ... -
An investigation of structure-function relations in articular cartilage during skeletal maturation
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)The over-riding objective of this thesis was to build upon our current understanding of the evolving nature of articular cartilage mechanics by elucidating how changes to structure and composition of the tissue during ... -
Assessing brain and cognitive function in multiple sclerosis cross-sectionally and longitudinally with multimodal methods : insights form high-density electrophysiology, neuropsychological examination and magnetic resonance imaging
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Cognitive impairment (CI) affects up to 65% of multiple sclerosis (MS) patients and can occur in the absence of physical disability (Hoffmann, Tittgemeyer, & von Cramon, 2007). MS is the most common chronic inflammatory ... -
Computational investigations of mesenchymal stem cell ageing in mechanobiological simulations of tissue differentiation
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)Musculoskeletal health is a major determinant of the quality of life for the increasing aged population groups in our society. Improved healthcare is essential to ensure successful ageing and enhanced musculoskeletal health ... -
Development of neural engineering methods for objective assessment of cognitive processing based on Gait Data : an analysis of a truly nationally representative cohort of older adults
(Trinity College (Dublin, Ireland). Department of Electronic & Electrical Engineering, 2015)Knowledge of the brain substrates and neural networks at play during gait are not well understood. However, strong associations between gait and cognitive function have been found in literature. Examining this relationship ... -
Engineering tissues with a zonal structure and composition mimicking native articular cartilage
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2015)Engineering cartilage grafts with comparable functionality to the native tissue remains a major challenge in the field of regenerative medicine. The overall goal of this thesis was to engineer a cartilage graft with ... -
Mechanoregulated tissue organisation during skeletal repair : a computational study
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)Articular cartilage is a highly specialised bearing material that provides low friction, wear resistant contact between the ends of articulating bones in diarthrodial joints. In order to function in this mechanically ... -
Methods of signal processing applied to speech and language for objective assessment of cognitive function in ageing and psychiatry
(Trinity College (Dublin, Ireland). Department of Electronic & Electrical Engineering, 2014)Ageing is associated with a change in cognitive function. Impaired cognitive function is the biggest limiting factor to independence in older adults. Cognitive decline does not appear suddenly, but occurs gradually over ... -
Microcrack distributions in bone : effects of stress and bone mineral density
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The work is divided into four main sections. Chapter 2 it was performed compression and bending tests, with the use of a dye sequence technique. The tests were carried out to detect and measure microdamage development after ... -
Quantitative assessment of perceptual, motor and cognitive function in Parkinson's disease and their contribution to freezing of gait
(Trinity College (Dublin, Ireland). Department of Electronic & Electrical Engineering, 2016) -
Stochastic failure modelling of total hip replacement
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Failure of total hip replacement (THR) can be a highly variable phenomenon. Many factors of a different nature may affect the outcome of this operation, e.g. loads occuring in the joint, patient geometry, implant design, ... -
The effect of mechanical cues on the chondrogenic differentiation of bone marrow derived mesenchymal stem cells
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)Tissue engineering strategies utilising mesenchymal stem cells (MSCs) represent a promising treatment option for a range of injuries and diseases. If MSCs are to be implanted in vivo, understanding the intricacies of how ... -
The mechanics of wound closure for laparoscopic surgery
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)The increase in popularity of laparoscopic surgery over the past 25 years has led to a greater importance of reducing the incidence of complications associated with the surgery. Development of a hernia at a trocar port ... -
The relationship between micro-structure and mechanical behaviour in passive skeletal muscle
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)This thesis presents and discusses investigative work performed on characterising the behavioural response of skeletal muscle tissue that was subjected to large deformations. The passive mechanical properties of muscle ... -
Tissue engineering scaled-up anatomically shaped osteochondral constructs for joint resurfacing
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2014)Partial and total joint replacements are the only surgical procedures currently available to treat articular cartilage degeneration associated with degenerative diseases such as osteoarthritis (OA). While these procedures ...