dc.contributor.author | Dorman, Charles | |
dc.date.accessioned | 2019-08-19T07:31:49Z | |
dc.date.available | 2019-08-19T07:31:49Z | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019 | en |
dc.identifier.citation | Dorman, Charles. DNA supercoiling and transcription: a two-way street, BMC Molecular and Cell Biology, 2019, 20:26 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/89211 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Background : The processes of DNA supercoiling and transcription are interdependent because the movement of a transcription elongation complex simultaneously induces under- and over winding of the DNA duplex and because the initiation, elongation and termination steps of transcription are all sensitive to the topological state of the DNA. Results: Policing of the local and global supercoiling of DNA by topoisomerases helps to sustain the major DNA-based transactions by eliminating barriers to the movement of transcription complexes and replisomes. Recent data from whole-genome and single-molecule studies have provided new insights into how interactions between transcription and the supercoiling of DNA influence the architecture of the chromosome and how they create cell-to-cell diversity at the level of gene expression through transcription bursting. Conclusions: These insights into fundamental molecular processes reveal mechanisms by which bacteria can prevail in unpredictable and often hostile environments by becoming unpredictable themselves | en |
dc.format.extent | 26 | en |
dc.format.extent | 35 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | BMC Molecular and Cell Biology; | |
dc.relation.ispartofseries | 20; | |
dc.rights | Y | en |
dc.subject | DNA supercoiling | en |
dc.subject | Transcription | en |
dc.subject.lcsh | DNA supercoiling and transcription | en |
dc.title | DNA supercoiling and transcription: a two-way street | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/cjdorman | |
dc.identifier.rssinternalid | 205438 | |
dc.identifier.doi | http://dx.doi.org/10.1186/s12860-019-0211-6 | |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Genes & Society | en |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.orcid_id | 0000-0002-6018-9170 | |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.contributor.sponsorGrantNumber | 13/IA/1875 | en |