DNA supercoiling and transcription: a two-way street
Citation:
Dorman, Charles. DNA supercoiling and transcription: a two-way street, BMC Molecular and Cell Biology, 2019, 20:26Download Item:
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Abstract:
Background : The processes of DNA supercoiling and transcription are interdependent because the movement of a transcription elongation complex simultaneously induces under- and over winding of the DNA duplex and because the initiation, elongation and termination steps of transcription are all sensitive to the topological state of the DNA. Results: Policing of the local and global supercoiling of DNA by topoisomerases helps to sustain the major DNA-based transactions by eliminating barriers to the movement of transcription complexes and replisomes. Recent data from whole-genome and single-molecule studies have provided new insights into how interactions between transcription and the supercoiling of DNA influence the architecture of the chromosome and how they create cell-to-cell diversity at the level of gene expression through transcription bursting. Conclusions: These insights into fundamental molecular processes reveal mechanisms by which bacteria can prevail in unpredictable and often hostile environments by becoming unpredictable themselves
Sponsor
Grant Number
Science Foundation Ireland (SFI)
13/IA/1875
Author's Homepage:
http://people.tcd.ie/cjdormanDescription:
PUBLISHED
Author: Dorman, Charles
Type of material:
Journal ArticleCollections:
Series/Report no:
BMC Molecular and Cell Biology;20;
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Full text availableKeywords:
DNA supercoiling, TranscriptionSubject (TCD):
Genes & Society , Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1186/s12860-019-0211-6Licences: