Endothelium as a target in the design of novel tumour antiangiogenic / vasculature-targeting agents
Citation:
Martina White, 'Endothelium as a target in the design of novel tumour antiangiogenic / vasculature-targeting agents', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008, pp 328Download Item:
Abstract:
This thesis begins with a review of tumour growth and development, with a particular focus on angiogenesis. The numerous mechanisms which regulate the process are touched upon, with current and fiiture antiangiogenic agents reviewed. This leads on to a discussion on tumour vasculature targeting agents and their role in chemotherapy, where tubulin binding agents are emphasised. The tumour angiogenesis/vasculature targeting agent, combretastatin A-4 is discussed in detail as are the different derivatives that have been synthesised based on this tubulin inhibitor. This leads onto a discussion on aminopeptidase N (APN), its role in cancer and more specifically in tumour angiogenesis. Finally, the concept of creating a hybrid type inhibitor of tumour angiogenesis/vasculature by incorporating both tubulin binding and APN inhibitory peptidal moieties into a single compound is presented.
Author: White, Martina
Advisor:
Walsh, JohnQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical SciencesNote:
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Full text availableKeywords:
Pharmacy, Ph.D., Ph.D. Trinity College DublinMetadata
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