Browsing by Subject "Pharmacy, Ph.D."
Now showing items 1-20 of 28
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A novel method for the measurement of flow-induced platelet activation at nanoscale resolution level
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Background: Platelet aggregation Is essential for vascular haemostasis and thrombosis. Inhibition of platelet aggregation underpins the pharmacological and clinical effects of antiplatelet drugs. These effects are commonly ... -
An exploration of the role of community pharmacists in health promotion in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)A combination of qualitative and quantitative methodologies was used to explore the research questions from a number of different angles. A literature review was carried out to identify work which had already been published ... -
An investigation of the potential anti-inflammatory properties of novel compounds with respect to LFA-1 mediated T cell motility and cytotoxicity profiling
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The aim of this thesis was to investigate the effects in vitro of novel compounds on LFA-1 mediated T cell motility, and, to develop a profile of the compounds with respect to cytotoxicity and apoptosis. The compounds ... -
Caffeine exacerbates the toxicity of 3,4 methylenedioxymethamphetamine (MDMA, Ecstasy ) : a role for dopamine
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Co-administration of caffeine profoundly enhances the acute toxicity of the substituted amphetamine 3, 4-methylenedioxymethamphetamine (MDMA “Ecstasy”) in rats, evidenced by high body temperature, tachycardia and increased ... -
Characterisation of drug transporters in human respiratory epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Cell culture models are an efficient and relatively cheap tool to study isolated mechanisms of an organ. The right cell model, carefully selected to allow highest benefits, can give valuable information in the area of ... -
Design, synthesis and evaluation of novel tumour vasculature-targeting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)This thesis is introduced with a review of the 'Hallmarks of Cancer', outlining each one as a potential target for drug therapy. Vascular targeting as a means of cancer growth retardation is specifically discussed. The ... -
Drug transport across the human respiratory epithelial barrier
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Drug transporters have only recently moved into the centre of attention of pulmonary drug delivery research, and of the more than 400 identified transporter proteins, only little information is available. In a first step, ... -
Endothelium as a target in the design of novel tumour antiangiogenic / vasculature-targeting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)This thesis begins with a review of tumour growth and development, with a particular focus on angiogenesis. The numerous mechanisms which regulate the process are touched upon, with current and fiiture antiangiogenic agents ... -
Functional expression of the epithelial sodium channel δ-subunit in human respiratory epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Mammalian amiloride-sensitive epithelial Na+ channel (ENaC) can be composed by different combinations of four homologous subunits, α, β, γ and δ. The canonical αβγ- ENaC, abundantly expressed in Na+ absorbing epithelia, ... -
Influence of anti-inflammatory interventions in the Kainic acid model of hippocampal excitotoxicity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Excitotoxicity is implicated as a mechanism of neuronal cell death in a range of neurodegenerative disorders. Such toxicity can be induced experimentally by systemic administration of the glutamate kainate receptor agonist, ... -
Investigation into bile acid effects on the golgi apparatus, cell viability and glucocorticoid receptor distribution in esophageal cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Bile acids are a family of steroidal molecules derived from cholesterol and biosynthesised in the pericentral hepatocytes in the liver. In recent years there has been a renaissance in bile acid based research as it has ... -
Investigation of cerebral perfusion changes following MDMA Ecstasy administration in an animal model using bolus-tracking arterial spin labelling MRI
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The recreational drug of abuse 3,4 methylenedioxymethamphetamine (MDMA; Ecstasy) carries a risk of cerebrovascular accidents (CVA) that may relate to the role of serotonin (5- HT) and/or dopamine in the regulation of ... -
Investigations into the anti allergy properties of novel benzocycloalkanone based compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)An allergic response occurs because of a hypersensitive response by mast cells to an otherwise innocuous environmental substance. Allergen challenge causes mast cell degranulation, resulting in the release of mast cell ... -
Kinetic and structural studies of novel isosorbide-based ligand binding to esterase enzymes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The main goal of the project described herein was to examine and rationalise the binding of a novel class of compound based on isosorbide to cholinesterase enzymes. The compounds of interest had been prepared within the ... -
Liposomes as carriers for systemic delivery of salmon calcitonin by inhalation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The concept of delivering proteins and peptides to the systemic circulation via the lungs has been extensively investigated over the last 20 years. Main drivers for the approach are the lungs’ high surface area, presumed ... -
Multimodal magnetic resonance imaging in animal models of depression
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Depression Is a debilitating and potentially fatal disorder for which the pathophysiology underlying the illness is still unknown. Aberrant glutamatergic neurotransmission and altered astrocyte function have recently been ... -
Optimisation of pulmonary drug delivery of the model peptide drug, salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The use of the pulmonary route is a viable alternative administration route to injection, in particular for drugs with poor systemic bioavailability upon oral delivery such as therapeutic peptides and proteins. However, ... -
Pharmaceutical stability and prodrug studies on the antidepressant bupropion
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)This thesis describes the work carried out at the School of Pharmacy and Pharmaceutical Sciences, Trinity College on the pharmaceutical stability and prodrug studies on the antidepressant bupropion. Chapter 1 gives an ... -
Prevalence, patterns and factors associated with multiple medicines use in an ageing poulation with intelletual disability in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)The provision of rational and appropriate pharmacotherapy to older people with intellectual disabilities (ID) poses significant challenges due to the complexities of conditions being treated, the increased risks of adverse ... -
Studies on the design, synthesis and stability of novel anti-allergy agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The purpose of this project was to design and synthesise novel classes of anti-allergy compounds using 1-tetralone as the principal building block. This thesis is introduced with an overview of the prominent role played ...