Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus.
File Type:
PDFItem Type:
Journal ArticleDate:
2014Access:
openAccessCitation:
Misstear K, McNeela EA, Murphy AG, Geoghegan JA, O'Keeffe KM, Fox J, Chan K, Heuking S, Collin N, Foster TJ, McLoughlin RM, Lavelle EC, Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus., The Journal of infectious diseases, 209, 9, 2014, 1479-1484Download Item:
J Infect Dis.-2014-Misstear-1479-84.pdf (Published (author's copy) - Peer Reviewed) 614.5Kb
Abstract:
Despite showing promise in preclinical models, anti–Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have not been studied to formally test whether a cellular-only response can protect against infection. We demonstrate that nasal vaccination with targeted nanoparticles loaded with Staphylococcus aureus antigen protects against acute systemic S. aureus infection in the absence of any antigen-specific antibodies. These findings can help inform future developments in staphylococcal vaccine development and studies into the requirements for protective immunity against S. aureus.
Author's Homepage:
http://people.tcd.ie/geoghejohttp://people.tcd.ie/lavellee
http://people.tcd.ie/mclougrm
http://people.tcd.ie/tfoster
Description:
PUBLISHEDType of material:
Journal ArticleCollections:
Series/Report no:
The Journal of infectious diseases209
9
Availability:
Full text availableKeywords:
nanoparticle, adjuvant, mucosal, cellular immunity, Staphylococcus aureus, vaccineSubject (TCD):
Immunology, Inflammation & Infection , Nanoscience & MaterialsDOI:
http://dx.doi.org/10.1093/infdis/jit636ISSN:
0022-1899Licences: