Browsing by Subject "Staphylococcus aureus"
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Characterisation of Staphylococcal and Candida Populations from Healthy and Diseased Oral and Subgingival Sites Reveals a High Prevalence and Diversity of the Arginine Catabolic Mobile Element ACME in Staphylococcus epidermidis
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2018)The oral cavity harbours a diverse microbiological population, that exists mainly as plaque biofilm, the accumulation of which is associated with oral diseases such as periodontal disease and peri-implantitis. Traditionally, ... -
Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus, and decreases complement-mediated phagocytosis
(2010)The human complement system is important in the immunological control of Staphylococcus aureus infection. We showed previously that S. aureus surface protein clumping factor A (ClfA), when expressed in recombinant form, ... -
Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target
(2019)Staphylococcus aureus expresses a number of cell wall-anchored proteins that mediate adhesion and invasion of host cells and tissues and promote immune evasion, consequently contributing to the virulence of this organism. ... -
Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.
(2013)Staphylococcus aureus is a premier human pathogen and the most common cause of osteoarticular, wound, and implanted device infections. We recently demonstrated S. aureus efficiently binds the classical complement regulator ... -
Current Perspectives Series: Filaggrin in Atopic Dermatitis
(Elsevier, 2008)The recent identification of loss-of-function mutations in the structural protein filaggrin as a widely replicated major risk factor for eczema sheds new light on disease mechanisms in eczema, a disease that had heretofore ... -
DETECTION OF mecC-POSITIVE Staphylococcus aureus (CC130-MRSA-XI) IN DISEASED EUROPEAN HEDGEHOGS (Erinaceus europaeus) IN SWEDEN
(2013)Recently, a novel mec gene conferring beta-lactam resistance in Staphylococcus aureus has been discovered. This gene, mecC, is situated on a SCCmec XI element that has to date been identified in clonal complexes 49, 130, ... -
DNA MICROARRAY GENOTYPING AND VIRULENCE AND ANTIMICROBIAL RESISTANCE GENE PROFILING OF METHICILLIN-RESISTANT Staphylococcus aureus BLOODSTREAM ISOLATES FROM RENAL PATIENTS
(2011)Thirty-six methicillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from renal patients were genetically characterized by DNA microarray analysis and spa typing. The isolates were highly clonal, belonging ... -
Emergence of the Epidemic Methicillin-Resistant Staphylococcus aureus Strain USA300 Coincides with Horizontal Transfer of the Arginine Catabolic Mobile Element and speG-mediated Adaptations for Survival on Skin.
(2013)The arginine catabolic mobile element (ACME) is the largest genomic region distinguishing epidemic USA300 strains of methicillin-resistant Staphylococcus aureus (MRSA) from other S. aureus strains. However, the functional ... -
Evolutionary Genomics of Staphylococcus aureus Reveals Insights into the Origin and Molecular Basis of Ruminant Host Adaptation
(Oxford University Press, 2010)Phenotypic biotyping has traditionally been used to differentiate bacteria occupying distinct ecological niches such as host species. For example, the capacity of Staphylococcus aureus from sheep to coagulate ruminant ... -
EXPERIMENTAL STAPHYLOCOCCUS AUREUS INFECTION OF THE MAMMARY GLAND INDUCES REGION-SPECIFIC CHANGES IN INNATE IMMUNE GENE EXPRESSION
(Elsevier, 2011)Staphylococcus aureus is a prolific mastitis-causing bacterium that resides naturally in the environment of the dairy cow. The aim of this study was to profile immune gene expression in tissue from the alveolar, ductal, ... -
Fibronectin binding proteins are required for biofilm formation by community-associated methicillin resistant Staphylococcus aureus strain LAC
(2014)Community-associated methicillin-resistant Staphylococcus aureus of the USA300 lineage is emerging as an important cause of medical device-related infection. However, few factors required for biofilm accumulation by USA300 ... -
Genetic analysis of gentamicin resistance in methicillin- and gentamicin-resistant strains of Staphylococcus aureus isolated in Dublin hospitals.
(American Society for MIcrobiology, 1988)Methicillin- and gentamicin-resistant strains of Staphylococcus aureus isolated in Dublin hospitals have been classified into groups I, II, and III based on resistance to antimicrobial agents and plasmid profiles. Each ... -
IDENTIFICATION AND CHARACTERIZATION OF THE MULTIDRUG RESISTANCE GENE cfr IN PANTON-VALENTINE LEUKOCIDIN-POSITIVE ST8-METHICILLIN-RESISTANT Staphylococcus aureus-IVa (USA300)
(2010)The staphylococcal cfr gene mediates resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A, a phenotype that has been termed PhLOPSA. The cfr gene has mainly been associated with ...
