Browsing Microbiology by Author "BELL, ANGUS"
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Anti-disease therapy for malaria: 'resistance proof'?
BOEHM, DANIELA; BELL, ANGUS (2013)Antimalarial drugs have in the past fallen prey to resistance and this problem is likely to continue in the future. One approach to developing drugs that might be less prone to resistance might be to target the disease ... -
Anti-malarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds
BELL, ANGUS (University of Chicago Press, 2005)The polyketide macrolactone FK506 inhibits the growth of Plasmodium falciparum in culture and the enzymatic (peptidyl-prolyl cis-trans isomerase [PPIase]) and chaperone activities of a recently identified P. falciparum ... -
Antimalarial drug discovery and design in the Era of resistance
BELL, ANGUS (2013)These are interesting times for antimalarial drug research. On the one hand, recent reports from Southeast Asia paint a grim picture of reduced malarial parasite susceptibility to artemisinin combination therapies ... -
Antimalarial peptides: the long and the short of it
BELL, ANGUS (2011)Antimicrobial peptides include a diverse array of both natural and synthetic molecules varying greatly in size, charge, hydrophobicity and secondary-structural features. Although better known as antibacterial agents, many ... -
Antimitotic herbicides bind to an unidentifed site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites.
BELL, ANGUS; DEMPSEY, ENDA (2013)Malarial parasites are exquisitely susceptible to a number of microtubule inhibitors but most of these compounds also affect human microtubules. Herbicides of the dinitroaniline and phosphorothioamidate classes however ... -
Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion
BELL, ANGUS (2015)The purpose of this study was to investigate the blood stage of the malaria causing parasite, Plasmodium falciparum, to predict potential protein interactions between the parasite merozoite and the host erythrocyte and ... -
Downstream Effects of Haemoglobinase Inhibition in Plasmodium falciparum-Infected Erythrocytes
BELL, ANGUS (2010)Blood-stage malarial parasites (Plasmodium falciparum) digest large quantities of host haemoglobin during their asexual development in erythrocytes. The haemoglobin digestion pathway, involving a succession of cleavages ... -
A family of cyclophilin-like molecular chaperones in Plasmodium falciparum
MARIN MENENDEZ, ALEJANDRO; BELL, ANGUS (2012)The cyclophilins are a large family of proteins implicated in folding, transport and regulation of other proteins and are potential drug targets in cancer and in some viral and parasitic infections. The functionality of ... -
Identification and characterization of novel Plasmodium falciparum cyclophilins and their roles in the antimalarial actions of cyclosporin A and derivatives
BELL, ANGUS; MARIN MENENDEZ, ALEJANDRO (BioMed Central, 2010)Cyclophilins are distributed widely among different organisms and are proposed drug targets for a number of diseases including HIV and hepatitis C infection and ischemia. Cyclophilins play roles in folding and chaperoning ... -
Immunophilin-protein interactions in Plasmodium falciparum.
BELL, ANGUS; BELL, ANGUS (2015)Immunophilins comprise two protein families, cyclophilins (CYPs) and FK506-binding proteins (FKBPs), and are the major receptors for the immunosuppressive drugs cyclosporin A (CsA) and FK506 (tacrolimus), respectively. ... -
Overexpression, purification and assessment of cyclosporin binding of a family of cyclophilins and cyclophilin-like proteins of the human malarial parasite Plasmodium falciparum
BELL, ANGUS; MARIN MENENDEZ, ALEJANDRO (2011)Malaria represents a global health, economic and social burden of enormous magnitude. Chemotherapy is at the moment a largely effective weapon against the disease, but the appearance of drug-resistant parasites is reducing ... -
PEST sequences in the malaria parasite Plasmodium falciparum: a genomic study
BELL, ANGUS (BioMed Central, 2003)Anopheles gambiae is the main vector of Plasmodium falciparum in Africa. The mosquito midgut constitutes a barrier that the parasite must cross if it is to develop and be transmitted. Despite the central role of the mosquito ... -
Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.
BELL, ANGUS (Elsevier, 2009)We have selected piperaquine (PQ) and lumefantrine (LM) resistant Plasmodium berghei ANKA parasite lines in mice by drug pressure. Effective doses that reduce parasitaemia by 90% (ED90) of PQ and LM against the parent line ... -
Simply red: A novel spectrophotometric erythroid proliferation assay as a tool for erythropoiesis and erythrotoxicity studies
BELL, ANGUS; BOEHM, DANIELA (2014)Most mammalian cell proliferation assays rely on manual or automated cell counting or the assessment of metabolic activity in colorimetric assays, with the former being either labor and time intensive or expensive and the ... -
Synthesis and evaluation of phenoxyoxazaphospholidine, phenoxyoxazaphosphinane, and benzodioxaphosphininamine sulfides and related compounds as potential anti-malarial agents
BELL, ANGUS; DEMPSEY, ENDA (2013)A series of phenoxyoxazaphospholidine, phenoxyoxazaphosphinane and benzodioxaphosphininamine sulfides and related cyclic organophosphorus compounds based on the lead anti-tubulin herbicides amiprophos methyl and butamifos ... -
Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents
BELL, ANGUS; DEMPSEY, ENDA (Elsevier, 2011)A series of phosphoramidate and phosphorothioamidate compounds based on the lead antitubulin herbicidal agents amiprophos methyl (APM) and butamifos were synthesised and evaluated for antimalarial activity. Of these ... -
Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution
BELL, ANGUS (2015)Antimalarial chemotherapy continues to be challenging in view of the emergence of drug resistance, especially artemisinin resistance in Southeast Asia. It is critical that we identify novel anti-malarial drugs that inhibit ...