Recent insights into the role of Toll-like receptors in viral infection.
Citation:
Carty M, Bowie AG, Recent insights into the role of Toll-like receptors in viral infection., Clinical and experimental immunology, 161, 3, 2010, 397-406Download Item:
CartyBowie author version.pdf (Published (author's copy) - Peer Reviewed) 3.081Mb
Abstract:
Toll-like receptors have a central role in innate immunity as they detect conserved pathogen
associated molecular patterns (PAMPs) on a range of microbes including viruses, leading to
innate immune activation and orchestration of the adaptive immune response. To date a large
number of viruses have been shown to trigger innate immunity via TLRs suggesting that these
receptors are likely to be important in the outcome to viral infection. This suggestion is
supported by the observation that many viruses have evolved mechanisms not only to evade the
innate immune system but also to subvert it for the benefit of the virus. In this review we will
discuss earlier evidence, mainly from knockout mice studies, implicating TLRs in the innate
immune response to viruses, in light of more recent clinical data demonstrating that TLRs are
important for anti-viral immunity in humans.
Author's Homepage:
http://people.tcd.ie/agbowieDescription:
PUBLISHED
Author: BOWIE, ANDREW
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Journal ArticleCollections:
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Clinical and experimental immunology161
3
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Toll-like receptorsDOI:
http://dx.doi.org/10.1111/j.1365-2249.2010.04196.xISSN:
0009-9104Licences: