Browsing by Author "BOWIE, ANDREW"
Now showing items 1-20 of 37
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A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
O'NEILL, LUKE; BOWIE, ANDREW (2000)Poxviruses employ many strategies to evade and neutralize the host immune response. In this study, we have identified two vaccinia virus ORFs, termed A46R and A52R, that share amino acid sequence similarity with the Toll/IL-1 ... -
A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival.
BOWIE, ANDREW (2014)Within innate immune signaling pathways, interleukin-1 receptor-associated kinases (IRAKs) fulfill key roles downstream of multiple Toll-like receptors and the interleukin-1 receptor. Although human IRAK4 deficiency was ... -
Cytosolic DNA sensors regulating type I interferon induction
BOWIE, ANDREW (2011)Type I interferon induction is a critical anti-pathogen response mediated by innate immune stimulation. While it has been appreciated for some time that the presence of pathogen DNA within a cell leads to a type I ... -
DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease
CUNNINGHAM, COLM; BOWIE, ANDREW; DUNNE, AISLING; COX, DONAL (2015)The detection of nucleic acids by the innate immune system is an essential host response during viral infection. In recent years, a number of immune sensors capable of recognizing cytosolic DNA have been identified and ... -
The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease.
BOWIE, ANDREW (2014)The innate immune response depends on the ability of immune cells to detect pathogens through germline-encoded pattern recognition receptors (PRRs). Recently discovered PRRs include some members of the Pyrin and HIN domain ... -
The history of Toll-like receptors-redefining innate immunity
O'NEILL, LUKE; BOWIE, ANDREW (2013)The discovery of Toll-like receptors (TLRs) was an important event for immunology research and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or Medicine to Jules Hoffmann and Bruce Beutler, ... -
HUMAN INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE-2 (IRAK-2) IS ESSENTIAL FOR TOLL-LIKE RECEPTOR-MEDIATED TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF TNFα
BOWIE, ANDREW (2011)Toll-like receptors (TLRs) are pattern recognition receptors that recognise microbial ligands and subsequently trigger intracellular signalling pathways involving transcription factors such as NF?B and MAPKs such ... -
IFI16 is an innate immune sensor for intracellular DNA
BOWIE, ANDREW (2010)The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA ... -
Innate DNA Sensing Moves to the Nucleus
BOWIE, ANDREW (2011)It has been assumed that cells distinguish viral from cellular DNA due to the former's presence in the cytosol. However, in this issue, Kerur et al. (2011) propose that the DNA genome of Kaposi's sarcoma-associated herpesvirus ... -
Innate immune detection of microbial nucleic acids
BOWIE, ANDREW (2013)Detection of pathogen-derived nucleic acids by pattern recognition receptors (PRRs) is essential for the host to mount an appropriate immune response, which for viruses involves the induction of type I interferons (IFNs). ... -
Innate immune recognition of DNA: A recent history.
BOWIE, ANDREW (2015) -
Innate sensing of bacterial cyclic dinucleotides: More than just STING
BOWIE, ANDREW (2012)Bacterial cyclic dinucleotides are recognised by the innate immune system, leading to induction of type I interferons. The mammalian helicase DDX41 directly binds cyclic dinucleotides and mediates the signaling pathway ... -
The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling
BOWIE, ANDREW; FLANNERY, SINEAD (Elsevier, 2010)The interleukin-receptor-associated kinase (IRAK) family are involved in regulating Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways. TLRs are pattern recognition receptors of the innate immune response ... -
The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
O'NEILL, LUKE; BOWIE, ANDREW (2000)The interleukin-1 (IL-1) receptor/Toll-like receptor (TLR) superfamily is a recently defined and expanding group of receptors that participate in host responses to injury and infection. The superfamily is defined by the ... -
Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
BOWIE, ANDREW (2017)STING is an innate immune cytosolic adaptor for DNA sensors that engage malaria parasite ( Plasmodium falciparum ) or other pathogen DNA. As P. falciparum infects red blood cells and not leukocytes, how parasite DNA ... -
Molluscum Contagiosum Virus protein MC005 inhibits NFκB activation by targeting NEMO-regulated IKK activation
BOWIE, ANDREW; BRADY, GARETH (2017) -
Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro.
BOWIE, ANDREW (2012)Background: The innate immune response in the brain is initiated by pathogen-associated molecular patterns (PAMPS) or danger-associated molecular patterns (DAMPS) produced in response to central nervous system (CNS) infection ... -
Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions.
BOWIE, ANDREW (2012)TLR4 signaling is inhibited by poxviral protein A46, but the mechanism is unknown. Results: We identify the protein interaction surfaces within the TLR4 complex that A46 antagonises, and characterize the interaction between ... -
The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defence
O'NEILL, LUKE; BOWIE, ANDREW (2003)Toll-like receptors (TLRs) are crucial in the innate immune response to pathogens, in that they recognize and respond to pathogen associated molecular patterns, which leads to activation of intracellular signaling pathways ...